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    Polr2d polymerase (RNA) II (DNA directed) polypeptide D [ Mus musculus (house mouse) ]

    Gene ID: 69241, updated on 8-Jul-2021

    Summary

    Official Symbol
    Polr2dprovided by MGI
    Official Full Name
    polymerase (RNA) II (DNA directed) polypeptide Dprovided by MGI
    Primary source
    MGI:MGI:1916491
    See related
    Ensembl:ENSMUSG00000024258
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RB; HSR; RBP4; HSRBP4; 2310002G05Rik; 2610028L19Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 39.1), CNS E14 (RPKM 31.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Polr2d in Genome Data Viewer
    Location:
    18; 18 B1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (31922178..31929762)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (31789125..31796709)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (31948813..31956355)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene AMME chromosomal region gene 1-like Neighboring gene predicted gene, 26533 Neighboring gene WD repeat domain 33 Neighboring gene glutathione S-transferase, mu 2 pseudogene Neighboring gene SFT2 domain containing 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation initiation factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of RNA polymerase II, core complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA-directed RNA polymerase II subunit RPB4
    Names
    DNA-directed RNA polymerase II subunit D
    RNA polymerase II subunit B4
    NP_001344409.1
    NP_081278.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357480.1NP_001344409.1  DNA-directed RNA polymerase II subunit RPB4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC161511, BM946715, BP770158, BU696372
      Consensus CDS
      CCDS89209.1
      Related
      ENSMUSP00000157052.2, ENSMUST00000234146.2
      Conserved Domains (1) summary
      cl00638
      Location:24109
      RNA_pol_Rpb4; RNA polymerase Rpb4
    2. NM_027002.4NP_081278.1  DNA-directed RNA polymerase II subunit RPB4 isoform 1

      See identical proteins and their annotated locations for NP_081278.1

      Status: VALIDATED

      Source sequence(s)
      AC161511, AK011600, BP770158, BU696372
      Consensus CDS
      CCDS29111.1
      UniProtKB/Swiss-Prot
      Q9D7M8
      Related
      ENSMUSP00000025106.4, ENSMUST00000025106.5
      Conserved Domains (1) summary
      smart00657
      Location:24141
      RPOL4c; DNA-directed RNA-polymerase II subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      31922178..31929762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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