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    Gtpbp4 GTP binding protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 69237, updated on 5-Aug-2018

    Summary

    Official Symbol
    Gtpbp4provided by MGI
    Official Full Name
    GTP binding protein 4provided by MGI
    Primary source
    MGI:MGI:1916487
    See related
    Ensembl:ENSMUSG00000021149
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NGB; Crfg; Nog1; Gtpbp3; 2610028C09Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 17.1), placenta adult (RPKM 10.1) and 23 other tissues See more
    Orthologs

    Genomic context

    See Gtpbp4 in Genome Data Viewer
    Location:
    13; 13 A1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (8972070..8996532, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (8971710..8995258, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L10A, pseudogene 2 Neighboring gene isopentenyl-diphosphate delta isomerase 2 pseudogene Neighboring gene isopentenyl-diphosphate delta isomerase 2 Neighboring gene predicted gene, 36264 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene La ribonucleoprotein domain family, member 4B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nucleolar GTP-binding protein 1
    Names
    GTP binding protein 3
    GTP-binding protein NGB
    Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB)
    chronic renal failure gene protein
    chronic renal failure protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027000.4NP_081276.2  nucleolar GTP-binding protein 1

      See identical proteins and their annotated locations for NP_081276.2

      Status: PROVISIONAL

      Source sequence(s)
      AC124732, AC125484
      Consensus CDS
      CCDS26236.1
      UniProtKB/Swiss-Prot
      Q99ME9
      Related
      ENSMUSP00000152412.1, ENSMUST00000222098.1
      Conserved Domains (3) summary
      cd01897
      Location:169340
      NOG; Nucleolar GTP-binding protein (NOG)
      COG1084
      Location:5345
      Nog1; GTP-binding protein, GTP1/Obg family [General function prediction only]
      pfam08155
      Location:396446
      NOGCT; NOGCT (NUC087) domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      8972070..8996532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315592.1XP_017171081.1  nucleolar GTP-binding protein 1 isoform X1

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