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    Selenot selenoprotein T [ Mus musculus (house mouse) ]

    Gene ID: 69227, updated on 31-Jan-2019

    Summary

    Official Symbol
    Selenotprovided by MGI
    Official Full Name
    selenoprotein Tprovided by MGI
    Primary source
    MGI:MGI:1916477
    See related
    Ensembl:ENSMUSG00000075700
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Selt; 2810407C02Rik; 5730408P04Rik
    Summary
    This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in mice indicate a crucial role for this gene in the protection of dopaminergic neurons against oxidative stress in Parkinson's disease, and in the control of glucose homeostasis in pancreatic beta-cells. A pseudogene of this locus has been identified on chromosome 8. [provided by RefSeq, Aug 2017]
    Expression
    Ubiquitous expression in kidney adult (RPKM 32.3), placenta adult (RPKM 31.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Selenot in Genome Data Viewer
    Location:
    3; 3 D
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (58576658..58593544)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (58380580..58397466)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene TSC22 domain family, member 2 Neighboring gene stress-associated endoplasmic reticulum protein 1 Neighboring gene eukaryotic translation initiation factor 2A Neighboring gene glutamate rich 6 Neighboring gene predicted gene, 46806 Neighboring gene spermine synthase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    thioredoxin-disulfide reductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell redox homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell redox homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular oxidant detoxification ISO
    Inferred from Sequence Orthology
    more info
     
    glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of growth hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    response to glucose IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    thioredoxin reductase-like selenoprotein T
    Names
    thioredoxin reductase-like enzyme
    NP_001035486.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040396.3NP_001035486.2  thioredoxin reductase-like selenoprotein T precursor

      See identical proteins and their annotated locations for NP_001035486.2

      Status: REVIEWED

      Source sequence(s)
      AA155383, AK013022, AK047958, BF660234, BY123391
      Consensus CDS
      CCDS38437.1
      UniProtKB/Swiss-Prot
      P62342
      Related
      ENSMUSP00000103557.1, ENSMUST00000107924.1
      Conserved Domains (1) summary
      cl01407
      Location:41179
      Rdx; Rdx family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      58576658..58593544
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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