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    Dhx16 DEAH-box helicase 16 [ Mus musculus (house mouse) ]

    Gene ID: 69192, updated on 21-Apr-2024

    Summary

    Official Symbol
    Dhx16provided by MGI
    Official Full Name
    DEAH-box helicase 16provided by MGI
    Primary source
    MGI:MGI:1916442
    See related
    Ensembl:ENSMUSG00000024422 AllianceGenome:MGI:1916442
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DBP2; Ddx16; mKIAA0577; 2410006N22Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be part of U2-type precatalytic spliceosome. Is expressed in several structures, including brain; gallbladder; genitourinary system; gut; and integumental system. Orthologous to human DHX16 (DEAH-box helicase 16). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 30.7), testis adult (RPKM 23.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    Location:
    17 B1; 17 18.74 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (36190657..36203562)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35879764..35892670)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene nurim (nuclear envelope membrane protein) Neighboring gene STARR-seq mESC enhancer starr_42480 Neighboring gene protein phosphatase 1, regulatory subunit 18 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:36016615-36016802 Neighboring gene RIKEN cDNA 2310061I04 gene Neighboring gene alpha tubulin acetyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E10949 Neighboring gene predicted gene 16279

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pattern recognition receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in intracellular anatomical structure IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
    Names
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 16
    DEAH (Asp-Glu-Ala-His) box polypeptide 16
    NP_081263.2
    XP_006524936.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026987.2NP_081263.2  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

      See identical proteins and their annotated locations for NP_081263.2

      Status: VALIDATED

      Source sequence(s)
      AI853344, AK010431, BC138205, BU054791, CJ141265
      Consensus CDS
      CCDS28710.1
      UniProtKB/TrEMBL
      G3X8X0, Q921Y1
      Related
      ENSMUSP00000025292.9, ENSMUST00000025292.15
      Conserved Domains (2) summary
      PTZ00121
      Location:147410
      PTZ00121; MAEBL; Provisional
      COG1643
      Location:3771031
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      36190657..36203562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524873.1XP_006524936.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1

      UniProtKB/TrEMBL
      Q921Y1
      Conserved Domains (2) summary
      PTZ00121
      Location:147410
      PTZ00121; MAEBL; Provisional
      COG1643
      Location:3771036
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    RNA

    1. XR_003952176.2 RNA Sequence

    2. XR_876528.4 RNA Sequence

      Related
      ENSMUST00000174366.8
    3. XR_001782109.3 RNA Sequence