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    Cdk12 cyclin-dependent kinase 12 [ Mus musculus (house mouse) ]

    Gene ID: 69131, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cdk12provided by MGI
    Official Full Name
    cyclin-dependent kinase 12provided by MGI
    Primary source
    MGI:MGI:1098802
    See related
    Ensembl:ENSMUSG00000003119
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crk7; Pksc; Crkrs; AI646528; D11Ertd752e; 1810022J16Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.5), limb E14.5 (RPKM 3.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cdk12 in Genome Data Viewer
    Location:
    11 D; 11 61.75 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (98202324..98281101)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (98064619..98114854)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene F-box and leucine-rich repeat protein 20 Neighboring gene mediator complex subunit 1 Neighboring gene ribosomal protein S6 pseudogene Neighboring gene predicted gene, 38963 Neighboring gene microRNA 5119 Neighboring gene predicted gene, 31194 Neighboring gene predicted gene, 31317

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC141525

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II CTD heptapeptide repeat kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II CTD heptapeptide repeat kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin binding ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription regulatory region DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    RNA splicing ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorylation of RNA polymerase II C-terminal domain IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphorylation of RNA polymerase II C-terminal domain ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription elongation from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
     
    transcription elongation from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin K-CDK12 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin/CDK positive transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cyclin-dependent kinase 12
    Names
    CDC2-related kinase 7
    CDC2-related kinase, arginine/serine-rich
    CDC2-related protein kinase 7
    cell division cycle 2-related protein kinase 7
    cell division protein kinase 12
    protein kinase for splicing component
    NP_001103096.1
    NP_001103098.1
    NP_081228.2
    XP_006534171.1
    XP_011247526.1
    XP_011247527.1
    XP_011247528.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109626.1NP_001103096.1  cyclin-dependent kinase 12 isoform 1

      See identical proteins and their annotated locations for NP_001103096.1

      Status: VALIDATED

      Source sequence(s)
      AA066711, AK049376, AL591205, BC116645
      Consensus CDS
      CCDS48901.1
      UniProtKB/Swiss-Prot
      Q14AX6
      Related
      ENSMUSP00000103162.1, ENSMUST00000107538.1
      Conserved Domains (2) summary
      smart00220
      Location:7231016
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:7151016
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    2. NM_001109628.1NP_001103098.1  cyclin-dependent kinase 12 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AA066711, AK129237, AL591205, BC116645
      Consensus CDS
      CCDS48902.1
      UniProtKB/Swiss-Prot
      Q14AX6
      Related
      ENSMUSP00000103163.1, ENSMUST00000107539.7
      Conserved Domains (2) summary
      smart00220
      Location:7231016
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:7151016
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    3. NM_026952.2NP_081228.2  cyclin-dependent kinase 12 isoform 3

      See identical proteins and their annotated locations for NP_081228.2

      Status: VALIDATED

      Source sequence(s)
      AA066711, AL591205, BC116645
      Consensus CDS
      CCDS25342.1
      UniProtKB/Swiss-Prot
      Q14AX6
      Related
      ENSMUSP00000003203.7, ENSMUST00000003203.13
      Conserved Domains (2) summary
      smart00220
      Location:7231016
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:7151016
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      98202324..98281101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534108.3XP_006534171.1  cyclin-dependent kinase 12 isoform X1

      Conserved Domains (2) summary
      smart00220
      Location:7221015
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:7141015
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    2. XM_011249225.2XP_011247527.1  cyclin-dependent kinase 12 isoform X3

      See identical proteins and their annotated locations for XP_011247527.1

      Conserved Domains (2) summary
      smart00220
      Location:7231016
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:7151016
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    3. XM_011249226.2XP_011247528.1  cyclin-dependent kinase 12 isoform X3

      See identical proteins and their annotated locations for XP_011247528.1

      Conserved Domains (2) summary
      smart00220
      Location:7231016
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:7151016
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    4. XM_011249224.2XP_011247526.1  cyclin-dependent kinase 12 isoform X2

      Conserved Domains (2) summary
      smart00220
      Location:7231016
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:7151016
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
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