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    Cnot8 CCR4-NOT transcription complex, subunit 8 [ Mus musculus (house mouse) ]

    Gene ID: 69125, updated on 3-Feb-2019

    Summary

    Official Symbol
    Cnot8provided by MGI
    Official Full Name
    CCR4-NOT transcription complex, subunit 8provided by MGI
    Primary source
    MGI:MGI:1916375
    See related
    Ensembl:ENSMUSG00000020515
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA536816; AU015770; AU043059; 1500015I04Rik; 1810022F04Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 34.1), CNS E14 (RPKM 23.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cnot8 in Genome Data Viewer
    Location:
    11; 11 B1.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (58092799..58118596)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (57917655..57932096)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene reduced expression 3 (Rex3) pseudogene Neighboring gene La ribonucleoprotein domain family, member 1 Neighboring gene predicted gene 12248 Neighboring gene predicted gene 12247 Neighboring gene gem nuclear organelle associated protein 5 Neighboring gene predicted gene, 33350 Neighboring gene mitochondrial ribosomal protein L22

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    3'-5'-exoribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    poly(A)-specific ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    poly(A)-specific ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay ISO
    Inferred from Sequence Orthology
    more info
     
    gene silencing by RNA IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    CCR4-NOT complex ISO
    Inferred from Sequence Orthology
    more info
     
    CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CCR4-NOT transcription complex subunit 8
    Names
    CCR4-associated factor 8
    NP_081225.1
    XP_006534165.1
    XP_006534166.1
    XP_006534167.1
    XP_006534168.1
    XP_006534169.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356477.2NP_001343406.1  CCR4-NOT transcription complex subunit 8

      Status: VALIDATED

      Source sequence(s)
      AK007581, AK075727, AK150757, BY419531
      Conserved Domains (1) summary
      cl23804
      Location:1263
      CAF1; CAF1 family ribonuclease
    2. NM_001363084.1NP_001350013.1  CCR4-NOT transcription complex subunit 8

      Status: VALIDATED

      Source sequence(s)
      AL672182, BB843287
      Conserved Domains (1) summary
      cl23804
      Location:1263
      CAF1; CAF1 family ribonuclease
    3. NM_001363085.1NP_001350014.1  CCR4-NOT transcription complex subunit 8

      Status: VALIDATED

      Source sequence(s)
      AL672182
      Conserved Domains (1) summary
      cl23804
      Location:1263
      CAF1; CAF1 family ribonuclease
    4. NM_001363086.1NP_001350015.1  CCR4-NOT transcription complex subunit 8

      Status: VALIDATED

      Source sequence(s)
      AL672182
      Conserved Domains (1) summary
      cl23804
      Location:1263
      CAF1; CAF1 family ribonuclease
    5. NM_026949.5NP_081225.1  CCR4-NOT transcription complex subunit 8

      See identical proteins and their annotated locations for NP_081225.1

      Status: VALIDATED

      Source sequence(s)
      AK075727, AK150757, BY419531, CD553562
      Consensus CDS
      CCDS24722.1
      UniProtKB/Swiss-Prot
      Q9D8X5
      Related
      ENSMUSP00000020822.5, ENSMUST00000020822.11
      Conserved Domains (1) summary
      cl23804
      Location:1263
      CAF1; CAF1 family ribonuclease

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      58092799..58118596
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534104.1XP_006534167.1  CCR4-NOT transcription complex subunit 8 isoform X1

      UniProtKB/Swiss-Prot
      Q9D8X5
      Conserved Domains (1) summary
      cl23804
      Location:1263
      CAF1; CAF1 family ribonuclease
    2. XM_006534102.1XP_006534165.1  CCR4-NOT transcription complex subunit 8 isoform X1

      See identical proteins and their annotated locations for XP_006534165.1

      UniProtKB/Swiss-Prot
      Q9D8X5
      Conserved Domains (1) summary
      cl23804
      Location:1263
      CAF1; CAF1 family ribonuclease
    3. XM_006534105.1XP_006534168.1  CCR4-NOT transcription complex subunit 8 isoform X1

      UniProtKB/Swiss-Prot
      Q9D8X5
      Conserved Domains (1) summary
      cl23804
      Location:1263
      CAF1; CAF1 family ribonuclease
    4. XM_006534103.3XP_006534166.1  CCR4-NOT transcription complex subunit 8 isoform X1

      UniProtKB/Swiss-Prot
      Q9D8X5
      Conserved Domains (1) summary
      cl23804
      Location:1263
      CAF1; CAF1 family ribonuclease
    5. XM_006534106.3XP_006534169.1  CCR4-NOT transcription complex subunit 8 isoform X1

      UniProtKB/Swiss-Prot
      Q9D8X5
      Related
      ENSMUSP00000104471.1, ENSMUST00000108843.7
      Conserved Domains (1) summary
      cl23804
      Location:1263
      CAF1; CAF1 family ribonuclease

    Reference GRCm38.p4 CAST/Ei

    Genomic

    1. NT_187029.1 Reference GRCm38.p4 CAST/Ei

      Range
      183346..184503 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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