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    Marchf5 membrane associated ring-CH-type finger 5 [ Mus musculus (house mouse) ]

    Gene ID: 69104, updated on 17-Aug-2021

    Summary

    Official Symbol
    Marchf5provided by MGI
    Official Full Name
    membrane associated ring-CH-type finger 5provided by MGI
    Primary source
    MGI:MGI:1915207
    See related
    Ensembl:ENSMUSG00000023307
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MI; MARC; Rnf1; MITOL; March5; Marchv; Rnf153; MARCH-V; 1810015H18Rik; 2310008I22Rik; 2700055A20Rik; 5730499H23Rik; E130202O05Rik
    Expression
    Ubiquitous expression in liver E14 (RPKM 15.2), CNS E14 (RPKM 13.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Marchf5 in Genome Data Viewer
    Location:
    19; 19 C2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (37184939..37201856)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (37207540..37224457)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (37282035..37298947)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene B-TFIID TATA-box binding protein associated factor 1 Neighboring gene cytoplasmic polyadenylation element binding protein 3 Neighboring gene RIKEN cDNA A330032B11 gene Neighboring gene predicted gene, 25268 Neighboring gene galactose-3-O-sulfotransferase 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC130121, MGC130122

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of cell aging ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase MARCHF5
    Names
    E3 ubiquitin-protein ligase MARCH5
    RING-type E3 ubiquitin transferase MARCH5
    RING-type E3 ubiquitin transferase MARCHF5
    membrane-associated RING finger protein 5
    membrane-associated RING-CH protein V
    membrane-associated ring finger (C3HC4) 5
    ring finger protein 153
    NP_001157808.1
    NP_001157809.1
    NP_001365726.1
    NP_001365727.1
    NP_081590.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164336.1NP_001157808.1  E3 ubiquitin-protein ligase MARCHF5 isoform 2

      See identical proteins and their annotated locations for NP_001157808.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK007511, AK009364, BY070559, CX733941
      Consensus CDS
      CCDS50427.1
      UniProtKB/Swiss-Prot
      Q3KNM2
      UniProtKB/TrEMBL
      A0A0R4J1H0
      Related
      ENSMUSP00000108010.2, ENSMUST00000112391.8
      Conserved Domains (1) summary
      cd16701
      Location:1272
      RING_CH-C4HC3_MARCH5; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH5 (MARCH5)
    2. NM_001164337.1NP_001157809.1  E3 ubiquitin-protein ligase MARCHF5 isoform 3

      See identical proteins and their annotated locations for NP_001157809.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC161238, AK007511, AK009364, AK021403, BY070559
      Conserved Domains (1) summary
      smart00744
      Location:1469
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
    3. NM_001378797.1NP_001365726.1  E3 ubiquitin-protein ligase MARCHF5 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC161238
      Conserved Domains (1) summary
      cd16701
      Location:1272
      RING_CH-C4HC3_MARCH5; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH5 (MARCH5)
    4. NM_001378798.1NP_001365727.1  E3 ubiquitin-protein ligase MARCHF5 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC161238
    5. NM_027314.3NP_081590.3  E3 ubiquitin-protein ligase MARCHF5 isoform 1

      See identical proteins and their annotated locations for NP_081590.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC161238, AK003478, AK009364, AK017741, BC132455, BY070559
      Consensus CDS
      CCDS29776.1
      UniProtKB/Swiss-Prot
      Q3KNM2
      UniProtKB/TrEMBL
      A2RTC8
      Related
      ENSMUSP00000024078.8, ENSMUST00000024078.15
      Conserved Domains (1) summary
      cd16701
      Location:1272
      RING_CH-C4HC3_MARCH5; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH5 (MARCH5)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      37184939..37201856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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