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    Ascc1 activating signal cointegrator 1 complex subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 69090, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ascc1provided by MGI
    Official Full Name
    activating signal cointegrator 1 complex subunit 1provided by MGI
    Primary source
    MGI:MGI:1916340
    See related
    Ensembl:ENSMUSG00000044475
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CGI-18; ASC1p50; AI550520; 1810015P09Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 16.8), kidney adult (RPKM 16.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ascc1 in Genome Data Viewer
    Location:
    10; 10 B4
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (60002479..60099990)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (59465587..59562734)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40673 Neighboring gene DNA-damage-inducible transcript 4 Neighboring gene anaphase promoting complex subunit 16 Neighboring gene sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2 Neighboring gene microRNA 6906 Neighboring gene carbohydrate sulfotransferase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    activating signal cointegrator 1 complex subunit 1
    Names
    ASC-1 complex subunit p50
    trip4 complex subunit p50

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199187.2NP_001186116.1  activating signal cointegrator 1 complex subunit 1

      See identical proteins and their annotated locations for NP_001186116.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK139944, AW457357
      Consensus CDS
      CCDS23870.1
      UniProtKB/Swiss-Prot
      Q9D8Z1
      Related
      ENSMUSP00000126301.2, ENSMUST00000164083.3
      Conserved Domains (3) summary
      PLN00108
      Location:128355
      PLN00108; unknown protein; Provisional
      cd02394
      Location:61119
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:132355
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    2. NM_026937.3NP_081213.1  activating signal cointegrator 1 complex subunit 1

      See identical proteins and their annotated locations for NP_081213.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK053811, AW457357, BC030905
      Consensus CDS
      CCDS23870.1
      UniProtKB/Swiss-Prot
      Q9D8Z1
      Related
      ENSMUSP00000052351.6, ENSMUST00000050516.13
      Conserved Domains (3) summary
      PLN00108
      Location:128355
      PLN00108; unknown protein; Provisional
      cd02394
      Location:61119
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:132355
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      60002479..60099990
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314074.1XP_017169563.1  activating signal cointegrator 1 complex subunit 1 isoform X4

    2. XM_017314075.1XP_017169564.1  activating signal cointegrator 1 complex subunit 1 isoform X5

    3. XM_006514039.2XP_006514102.1  activating signal cointegrator 1 complex subunit 1 isoform X1

      Conserved Domains (3) summary
      PLN00108
      Location:158385
      PLN00108; unknown protein; Provisional
      cd02394
      Location:91149
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:162385
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    4. XM_006514041.3XP_006514104.1  activating signal cointegrator 1 complex subunit 1 isoform X3

      See identical proteins and their annotated locations for XP_006514104.1

      Conserved Domains (2) summary
      PLN00108
      Location:84311
      PLN00108; unknown protein; Provisional
      pfam10469
      Location:88311
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    5. XM_006514040.3XP_006514103.1  activating signal cointegrator 1 complex subunit 1 isoform X2

      See identical proteins and their annotated locations for XP_006514103.1

      UniProtKB/Swiss-Prot
      Q9D8Z1
      Conserved Domains (3) summary
      PLN00108
      Location:128355
      PLN00108; unknown protein; Provisional
      cd02394
      Location:61119
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:132355
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    6. XM_006514042.3XP_006514105.1  activating signal cointegrator 1 complex subunit 1 isoform X3

      See identical proteins and their annotated locations for XP_006514105.1

      Conserved Domains (2) summary
      PLN00108
      Location:84311
      PLN00108; unknown protein; Provisional
      pfam10469
      Location:88311
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
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