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    Isca1 iron-sulfur cluster assembly 1 [ Mus musculus (house mouse) ]

    Gene ID: 69046, updated on 23-Jun-2021

    Summary

    Official Symbol
    Isca1provided by MGI
    Official Full Name
    iron-sulfur cluster assembly 1provided by MGI
    Primary source
    MGI:MGI:1916296
    See related
    Ensembl:ENSMUSG00000044792
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hbld; Hbld2; 1810010A06Rik
    Expression
    Ubiquitous expression in heart adult (RPKM 131.8), liver E14.5 (RPKM 87.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Isca1 in Genome Data Viewer
    Location:
    13; 13 B2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (59903229..59917603, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (59755415..59769789, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (59856776..59871150, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930528D03 gene Neighboring gene RIKEN cDNA 1700014D04 gene Neighboring gene ethanol decreased 2 Neighboring gene terminal uridylyl transferase 7 Neighboring gene predicted gene, 19866

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein maturation by iron-sulfur cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    iron-sulfur cluster assembly 1 homolog, mitochondrial
    Names
    HESB like domain containing 2
    HESB-like domain-containing protein 2
    iron-sulfur assembly protein IscA
    NP_081197.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026921.4NP_081197.1  iron-sulfur cluster assembly 1 homolog, mitochondrial precursor

      See identical proteins and their annotated locations for NP_081197.1

      Status: PROVISIONAL

      Source sequence(s)
      AC134869
      Consensus CDS
      CCDS26578.1
      UniProtKB/Swiss-Prot
      Q9D924
      Related
      ENSMUSP00000054858.7, ENSMUST00000057115.7
      Conserved Domains (1) summary
      TIGR00049
      Location:26129
      TIGR00049; Iron-sulfur cluster assembly accessory protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      59903229..59917603 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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