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    Thap7 THAP domain containing 7 [ Mus musculus (house mouse) ]

    Gene ID: 69009, updated on 18-Sep-2024

    Summary

    Official Symbol
    Thap7provided by MGI
    Official Full Name
    THAP domain containing 7provided by MGI
    Primary source
    MGI:MGI:1916259
    See related
    Ensembl:ENSMUSG00000022760 AllianceGenome:MGI:1916259
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810004B07Rik
    Summary
    Predicted to enable several functions, including C2H2 zinc finger domain binding activity; histone binding activity; and histone deacetylase binding activity. Predicted to be involved in negative regulation of histone acetylation and negative regulation of transcription by RNA polymerase II. Predicted to be located in nuclear membrane and nuclear speck. Predicted to be active in nucleus. Is expressed in early conceptus; heart; reproductive system; and urinary system. Orthologous to human THAP7 (THAP domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 39.8), adrenal adult (RPKM 37.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Thap7 in Genome Data Viewer
    Location:
    16 A3; 16 10.86 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17345823..17349975, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17527959..17531151, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene apoptosis-inducing factor, mitochondrion-associated 3 Neighboring gene leucine-zipper-like transcriptional regulator, 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:17531169-17531278 Neighboring gene leucine rich repeat containing 74B Neighboring gene STARR-positive B cell enhancer ABC_E10890 Neighboring gene STARR-seq mESC enhancer starr_40257 Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables C2H2 zinc finger domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables C2H2 zinc finger domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables general transcription initiation factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables general transcription initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone reader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone reader activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lysine-acetylated histone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methylated histone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphorylated histone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphorylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    THAP domain-containing protein 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026909.2NP_081185.1  THAP domain-containing protein 7

      See identical proteins and their annotated locations for NP_081185.1

      Status: PROVISIONAL

      Source sequence(s)
      AC113006
      Consensus CDS
      CCDS28004.1
      UniProtKB/Swiss-Prot
      Q8VCZ3
      UniProtKB/TrEMBL
      Q3U3Q2
      Related
      ENSMUSP00000097701.4, ENSMUST00000100125.12
      Conserved Domains (2) summary
      smart00980
      Location:493
      THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
      PHA03247
      Location:111221
      PHA03247; large tegument protein UL36; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      17345823..17349975 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246003.4XP_011244305.1  THAP domain-containing protein 7 isoform X4

      UniProtKB/TrEMBL
      A0A338P7J4
    2. XM_006522513.5XP_006522576.1  THAP domain-containing protein 7 isoform X3

      UniProtKB/TrEMBL
      Q3U3Q2
      Conserved Domains (1) summary
      PHA03247
      Location:59169
      PHA03247; large tegument protein UL36; Provisional
    3. XM_030249261.2XP_030105121.1  THAP domain-containing protein 7 isoform X2

      UniProtKB/TrEMBL
      Q3U3Q2
      Conserved Domains (1) summary
      smart00980
      Location:474
      THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
    4. XM_036160107.1XP_036016000.1  THAP domain-containing protein 7 isoform X4

      UniProtKB/TrEMBL
      A0A338P7J4
      Related
      ENSMUSP00000156319.2, ENSMUST00000232041.2
    5. XM_006522511.5XP_006522574.1  THAP domain-containing protein 7 isoform X1

      See identical proteins and their annotated locations for XP_006522574.1

      UniProtKB/Swiss-Prot
      Q8VCZ3
      UniProtKB/TrEMBL
      Q3U3Q2
      Related
      ENSMUSP00000156168.2, ENSMUST00000231548.2
      Conserved Domains (2) summary
      smart00980
      Location:493
      THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
      PHA03247
      Location:111221
      PHA03247; large tegument protein UL36; Provisional