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    Anapc10 anaphase promoting complex subunit 10 [ Mus musculus (house mouse) ]

    Gene ID: 68999, updated on 26-Sep-2022

    Summary

    Official Symbol
    Anapc10provided by MGI
    Official Full Name
    anaphase promoting complex subunit 10provided by MGI
    Primary source
    MGI:MGI:1916249
    See related
    Ensembl:ENSMUSG00000036977 AllianceGenome:MGI:1916249
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    APC10; 1500026N15Rik; A830003M23Rik
    Summary
    Predicted to be involved in protein K11-linked ubiquitination. Predicted to act upstream of or within cell division. Located in cytoplasm. Orthologous to human ANAPC10 (anaphase promoting complex subunit 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 2.3), CNS E14 (RPKM 2.2) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Anapc10 in Genome Data Viewer
    Location:
    8 C1; 8 37.79 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (80438366..80503950)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (79711736..79777321)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51579 Neighboring gene OTU domain containing 4 Neighboring gene tumor protein D52, pseudogene Neighboring gene ATP-binding cassette, sub-family E (OABP), member 1 Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene predicted gene, 30494 Neighboring gene Hedgehog-interacting protein Neighboring gene predicted gene, 39206

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of anaphase-promoting complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of anaphase-promoting complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    anaphase-promoting complex subunit 10
    Names
    cyclosome subunit 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357234.1NP_001344163.1  anaphase-promoting complex subunit 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC101714, AC158348, BB647573
      Consensus CDS
      CCDS22439.1
      UniProtKB/Swiss-Prot
      Q9CW24
      UniProtKB/TrEMBL
      A0A6P5Q2I9, A0A8C6IAN4
      Conserved Domains (1) summary
      pfam03256
      Location:4183
      ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)
    2. NM_001357235.1NP_001344164.1  anaphase-promoting complex subunit 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC101714, AC158348, AK041373
      Consensus CDS
      CCDS22439.1
      UniProtKB/Swiss-Prot
      Q9CW24
      UniProtKB/TrEMBL
      A0A6P5Q2I9, A0A8C6IAN4
      Related
      ENSMUSP00000148220.2, ENSMUST00000210812.2
      Conserved Domains (1) summary
      pfam03256
      Location:4183
      ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)
    3. NM_001357236.1NP_001344165.1  anaphase-promoting complex subunit 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC101714, AC158348, BQ178177
      Consensus CDS
      CCDS22439.1
      UniProtKB/Swiss-Prot
      Q9CW24
      UniProtKB/TrEMBL
      A0A6P5Q2I9, A0A8C6IAN4
      Conserved Domains (1) summary
      pfam03256
      Location:4183
      ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)
    4. NM_001357237.1NP_001344166.1  anaphase-promoting complex subunit 10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC101714, AC158348, BE863817
      Conserved Domains (1) summary
      cl02148
      Location:4111
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    5. NM_026904.3NP_081180.1  anaphase-promoting complex subunit 10 isoform a

      See identical proteins and their annotated locations for NP_081180.1

      Status: VALIDATED

      Source sequence(s)
      AC101714, AC158348, AK005303, CX567202
      Consensus CDS
      CCDS22439.1
      UniProtKB/Swiss-Prot
      Q8K2H6, Q9CW24
      UniProtKB/TrEMBL
      A0A6P5Q2I9, A0A8C6IAN4
      Related
      ENSMUSP00000048244.8, ENSMUST00000048147.9
      Conserved Domains (1) summary
      pfam03256
      Location:4183
      ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      80438366..80503950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243749.2XP_030099609.1  anaphase-promoting complex subunit 10 isoform X1

      Conserved Domains (1) summary
      cl02148
      Location:469
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    2. XM_006531342.2XP_006531405.1  anaphase-promoting complex subunit 10 isoform X2

      See identical proteins and their annotated locations for XP_006531405.1

      Conserved Domains (1) summary
      cl02148
      Location:4111
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    3. XM_030243751.1XP_030099611.1  anaphase-promoting complex subunit 10 isoform X3

      Conserved Domains (1) summary
      cl02148
      Location:469
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    4. XM_036154264.1XP_036010157.1  anaphase-promoting complex subunit 10 isoform X1

      Conserved Domains (1) summary
      cl02148
      Location:469
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    5. XM_036154266.1XP_036010159.1  anaphase-promoting complex subunit 10 isoform X3

      Conserved Domains (1) summary
      cl02148
      Location:469
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    6. XM_036154265.1XP_036010158.1  anaphase-promoting complex subunit 10 isoform X2

      Conserved Domains (1) summary
      cl02148
      Location:4111
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    7. XM_030243750.1XP_030099610.1  anaphase-promoting complex subunit 10 isoform X1

      Conserved Domains (1) summary
      cl02148
      Location:469
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination