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    Med27 mediator complex subunit 27 [ Mus musculus (house mouse) ]

    Gene ID: 68975, updated on 23-Jun-2021

    Summary

    Official Symbol
    Med27provided by MGI
    Official Full Name
    mediator complex subunit 27provided by MGI
    Primary source
    MGI:MGI:1916225
    See related
    Ensembl:ENSMUSG00000026799
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cr; Crsp8; AA682045; D2Ertd434; D2Ertd434e; 1500015J03Rik; 2310042P07Rik
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 6.7), CNS E14 (RPKM 6.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Med27 in Genome Data Viewer
    Location:
    2 B; 2 19.84 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (29236822..29414802)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (29346810..29524790)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (29202356..29380308)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene senataxin Neighboring gene RIKEN cDNA 6530402F18 gene Neighboring gene netrin G2 Neighboring gene microRNA 133c Neighboring gene predicted gene, 30761 Neighboring gene Rap guanine nucleotide exchange factor (GEF) 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mediator of RNA polymerase II transcription subunit 27
    Names
    CRSP complex subunit 8
    cofactor required for Sp1 transcriptional activation, subunit 8
    transcriptional co-activator CRSP8 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290489.1NP_001277418.1  mediator of RNA polymerase II transcription subunit 27 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two 5' exons but instead contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AI850753, AL772213, AL929437, CJ073494
      Consensus CDS
      CCDS79764.1
      UniProtKB/TrEMBL
      E0CZG8
      Related
      ENSMUSP00000125390.2, ENSMUST00000159280.8
      Conserved Domains (1) summary
      pfam11571
      Location:89167
      Med27; Mediator complex subunit 27
    2. NM_001290490.1NP_001277419.1  mediator of RNA polymerase II transcription subunit 27 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains alternate 5' and 3' exon structure, and it thus differs in both UTRs and in the 5' and 3' coding regions, compared to variant 1. The encoded isoform (d) has distinct N- and C-termini and is shorter than isoform a.
      Source sequence(s)
      AK147181, AL929437, CJ073494, DV648756
      UniProtKB/Swiss-Prot
      Q9DB40
    3. NM_026896.5NP_081172.2  mediator of RNA polymerase II transcription subunit 27 isoform a

      See identical proteins and their annotated locations for NP_081172.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AI850753, AK005251, CJ072886
      Consensus CDS
      CCDS15853.1
      UniProtKB/Swiss-Prot
      Q9DB40
      Related
      ENSMUSP00000028139.5, ENSMUST00000028139.11
      Conserved Domains (1) summary
      pfam11571
      Location:228306
      Med27; Mediator complex subunit 27
    4. NM_029615.1NP_083891.1  mediator of RNA polymerase II transcription subunit 27 isoform b

      See identical proteins and their annotated locations for NP_083891.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks four 3' exons but instead contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AK009764, AK147181, AL929437, CJ072886
      Consensus CDS
      CCDS71014.1
      UniProtKB/Swiss-Prot
      Q9DB40
      Related
      ENSMUSP00000109461.5, ENSMUST00000113830.11

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      29236822..29414802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319247.3XP_017174736.1  mediator of RNA polymerase II transcription subunit 27 isoform X2

    2. XM_017319246.1XP_017174735.1  mediator of RNA polymerase II transcription subunit 27 isoform X1

      Conserved Domains (1) summary
      pfam11571
      Location:115194
      Med27; Mediator complex subunit 27
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