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    Dcaf12 DDB1 and CUL4 associated factor 12 [ Mus musculus (house mouse) ]

    Gene ID: 68970, updated on 16-Oct-2021

    Summary

    Official Symbol
    Dcaf12provided by MGI
    Official Full Name
    DDB1 and CUL4 associated factor 12provided by MGI
    Primary source
    MGI:MGI:1916220
    See related
    Ensembl:ENSMUSG00000028436
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wdr40a; AA420338; AI851081; 1500001L20Rik; 5830424K06Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 28.9), liver E14 (RPKM 16.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Dcaf12 in Genome Data Viewer
    Location:
    4; 4 A5
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41291300..41316749, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41291300..41316749, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (41238333..41261934, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-associated protein 2 Neighboring gene predicted gene 12401 Neighboring gene predicted gene, 42273 Neighboring gene predicted gene, 26049 Neighboring gene predicted gene, 46891 Neighboring gene predicted gene, 26084 Neighboring gene ubiquitin-associated protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    DDB1- and CUL4-associated factor 12
    Names
    WD repeat domain 40A
    WD repeat-containing protein 40A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026893.3NP_081169.2  DDB1- and CUL4-associated factor 12

      See identical proteins and their annotated locations for NP_081169.2

      Status: VALIDATED

      Source sequence(s)
      AA207929, AK031089, AK173289, BY338453
      Consensus CDS
      CCDS18059.1
      UniProtKB/Swiss-Prot
      Q8BGZ3
      Related
      ENSMUSP00000030145.9, ENSMUST00000030145.9
      Conserved Domains (3) summary
      COG2319
      Location:103378
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:144180
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:85279
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      41291300..41316749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538230.4XP_006538293.1  DDB1- and CUL4-associated factor 12 isoform X4

      See identical proteins and their annotated locations for XP_006538293.1

    2. XM_006538229.4XP_006538292.1  DDB1- and CUL4-associated factor 12 isoform X2

      Conserved Domains (2) summary
      sd00039
      Location:120156
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:61255
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_006538228.4XP_006538291.1  DDB1- and CUL4-associated factor 12 isoform X1

      Conserved Domains (2) summary
      sd00039
      Location:138174
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:79273
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. XM_036164402.1XP_036020295.1  DDB1- and CUL4-associated factor 12 isoform X4

    5. XM_017320381.3XP_017175870.1  DDB1- and CUL4-associated factor 12 isoform X4

    6. XM_036164401.1XP_036020294.1  DDB1- and CUL4-associated factor 12 isoform X3

      Conserved Domains (2) summary
      sd00039
      Location:90130
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:85297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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