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    Tmco1 transmembrane and coiled-coil domains 1 [ Mus musculus (house mouse) ]

    Gene ID: 68944, updated on 23-Jun-2021

    Summary

    Official Symbol
    Tmco1provided by MGI
    Official Full Name
    transmembrane and coiled-coil domains 1provided by MGI
    Primary source
    MGI:MGI:1921173
    See related
    Ensembl:ENSMUSG00000052428
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ESTM3; ESTM39; AA109065; AU022572; 1190006A08Rik; 4930403O06Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 17.2), kidney adult (RPKM 12.2) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tmco1 in Genome Data Viewer
    Location:
    1; 1 H2.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (167136239..167161547)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (167308670..167333978)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (169238801..169264109)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene uridine-cytidine kinase 2 Neighboring gene uncharacterized LOC118567864 Neighboring gene microRNA 6347 Neighboring gene predicted gene, 24182 Neighboring gene aldehyde dehydrogenase 9, subfamily A1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ER overload response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in endoplasmic reticulum calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in endoplasmic reticulum calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endoplasmic reticulum calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    calcium load-activated calcium channel
    Names
    CLAC channel
    transmembrane and coiled-coil domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039483.1NP_001034572.1  calcium load-activated calcium channel precursor

      See identical proteins and their annotated locations for NP_001034572.1

      Status: VALIDATED

      Source sequence(s)
      AC113970, AK004504, AK037709
      Consensus CDS
      CCDS15456.1
      UniProtKB/Swiss-Prot
      Q921L3
      UniProtKB/TrEMBL
      Q3V4A0
      Related
      ENSMUSP00000142042.2, ENSMUST00000195015.6
      Conserved Domains (1) summary
      pfam01956
      Location:8165
      DUF106; Integral membrane protein DUF106

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      167136239..167161547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_026881.2: Suppressed sequence

      Description
      NM_026881.2: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
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