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    TALDO1 transaldolase 1 [ Homo sapiens (human) ]

    Gene ID: 6888, updated on 8-Jul-2021

    Summary

    Official Symbol
    TALDO1provided by HGNC
    Official Full Name
    transaldolase 1provided by HGNC
    Primary source
    HGNC:HGNC:11559
    See related
    Ensembl:ENSG00000177156 MIM:602063
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TAL; TALH; TAL-H; TALDOR
    Summary
    Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 165.6), esophagus (RPKM 127.9) and 25 other tissues See more
    Orthologs
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    Genomic context

    See TALDO1 in Genome Data Viewer
    Location:
    11p15.5
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (747464..765012)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (747464..765012)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene DEAF1 transcription factor Neighboring gene EPS8 like 2 Neighboring gene uncharacterized LOC105376509 Neighboring gene glutamine amidotransferase class 1 domain containing 1 Neighboring gene uncharacterized LOC171391

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables monosaccharide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transaldolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fructose 6-phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glyceraldehyde-3-phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pentose-phosphate shunt, non-oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    is_active_in intracellular anatomical structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus HDA PubMed 

    General protein information

    Preferred Names
    transaldolase
    Names
    dihydroxyacetone transferase
    glycerone transferase
    testicular secretory protein Li 56
    NP_006746.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008160.1 RefSeqGene

      Range
      5033..22581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006755.2NP_006746.1  transaldolase

      See identical proteins and their annotated locations for NP_006746.1

      Status: REVIEWED

      Source sequence(s)
      L19437
      Consensus CDS
      CCDS7712.1
      UniProtKB/Swiss-Prot
      P37837
      UniProtKB/TrEMBL
      A0A140VK56
      Related
      ENSP00000321259.3, ENST00000319006.8
      Conserved Domains (1) summary
      PRK05269
      Location:11329
      PRK05269; transaldolase B; Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      747464..765012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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