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    Prpf6 pre-mRNA splicing factor 6 [ Mus musculus (house mouse) ]

    Gene ID: 68879, updated on 8-Jul-2021

    Summary

    Official Symbol
    Prpf6provided by MGI
    Official Full Name
    pre-mRNA splicing factor 6provided by MGI
    Primary source
    MGI:MGI:1922946
    See related
    Ensembl:ENSMUSG00000002455
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ANT; ANT-1; U5-102K; 1190003A07Rik; 2610031L17Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 22.6), placenta adult (RPKM 18.6) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Prpf6 in Genome Data Viewer
    Location:
    2; 2 H4
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (181243112..181297454)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181601319..181655661)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (181336024..181390366)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene zinc finger protein 512B Neighboring gene microRNA 7006 Neighboring gene sterile alpha motif domain containing 10 Neighboring gene predicted gene, 29797 Neighboring gene predicted gene, 25879

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC11655, MGC36967, MGC38351

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in spliceosomal tri-snRNP complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in spliceosomal tri-snRNP complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of U4/U6 x U5 tri-snRNP complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of U5 snRNP ISO
    Inferred from Sequence Orthology
    more info
     
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    pre-mRNA-processing factor 6
    Names
    PRP6 homolog
    PRP6 pre-mRNA splicing factor 6 homolog
    U5 snRNP-associated 102 kDa protein
    U5-102 kDa protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133701.2NP_598462.1  pre-mRNA-processing factor 6

      See identical proteins and their annotated locations for NP_598462.1

      Status: VALIDATED

      Source sequence(s)
      AK081998, BY735790, CJ228927
      Consensus CDS
      CCDS38381.1
      UniProtKB/Swiss-Prot
      Q91YR7
      Related
      ENSMUSP00000002529.7, ENSMUST00000002529.7
      Conserved Domains (6) summary
      smart00386
      Location:444476
      HAT; HAT (Half-A-TPR) repeats
      sd00006
      Location:708738
      TPR; TPR repeat [structural motif]
      pfam06424
      Location:13169
      PRP1_N; PRP1 splicing factor, N-terminal
      pfam13414
      Location:709774
      TPR_11; TPR repeat
      pfam13428
      Location:404443
      TPR_14; Tetratricopeptide repeat
      pfam14559
      Location:621673
      TPR_19; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      181243112..181297454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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