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    Rnf122 ring finger protein 122 [ Mus musculus (house mouse) ]

    Gene ID: 68867, updated on 26-Sep-2022

    Summary

    Official Symbol
    Rnf122provided by MGI
    Official Full Name
    ring finger protein 122provided by MGI
    Primary source
    MGI:MGI:1916117
    See related
    Ensembl:ENSMUSG00000039328 AllianceGenome:MGI:1916117
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110063C11Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in cellular protein metabolic process; negative regulation of mitochondrial membrane potential; and positive regulation of apoptotic process. Predicted to be located in cytoplasm. Predicted to be active in endomembrane system. Orthologous to human RNF122 (ring finger protein 122). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in limb E14.5 (RPKM 11.2), CNS E11.5 (RPKM 10.1) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Rnf122 in Genome Data Viewer
    Location:
    8; 8 A3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (31601855..31623346)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (31111827..31133318)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 26 (putative) Neighboring gene predicted gene, 40484 Neighboring gene small nucleolar RNA, C/D box 13 Neighboring gene TELO2 interacting protein 2 Neighboring gene MAK16 homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    RING finger protein 122
    Names
    ring finger protein 122 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368373.1NP_001355302.1  RING finger protein 122 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC109163
    2. NM_001368374.1NP_001355303.1  RING finger protein 122 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC109163
    3. NM_001368375.1NP_001355304.1  RING finger protein 122 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC109163
      Consensus CDS
      CCDS90381.1
      UniProtKB/Swiss-Prot
      Q8BGD3
      Related
      ENSMUSP00000150893.2, ENSMUST00000217278.2
      Conserved Domains (1) summary
      cd16469
      Location:91137
      RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins
    4. NM_175136.3NP_780345.1  RING finger protein 122 isoform 4

      See identical proteins and their annotated locations for NP_780345.1

      Status: VALIDATED

      Source sequence(s)
      AC109163
      Consensus CDS
      CCDS22220.1
      UniProtKB/Swiss-Prot
      Q8BP31
      UniProtKB/TrEMBL
      A0A0R4J0G8
      Related
      ENSMUSP00000040478.8, ENSMUST00000046941.8
      Conserved Domains (1) summary
      cd16469
      Location:91136
      RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      31601855..31623346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)