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    Elovl5 ELOVL fatty acid elongase 5 [ Mus musculus (house mouse) ]

    Gene ID: 68801, updated on 9-Dec-2024

    Summary

    Official Symbol
    Elovl5provided by MGI
    Official Full Name
    ELOVL fatty acid elongase 5provided by MGI
    Primary source
    MGI:MGI:1916051
    See related
    Ensembl:ENSMUSG00000032349 AllianceGenome:MGI:1916051
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HELO1; 1110059L23Rik
    Summary
    Predicted to enable fatty acid elongase activity. Predicted to be involved in fatty acid biosynthetic process; positive regulation of fatty acid biosynthetic process; and sphingolipid biosynthetic process. Predicted to be located in dendritic tree; endoplasmic reticulum; and neuronal cell body. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 38. Orthologous to human ELOVL5 (ELOVL fatty acid elongase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver adult (RPKM 103.9), adrenal adult (RPKM 79.4) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Elovl5 in Genome Data Viewer
    Location:
    9 E1; 9 43.36 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (77824647..77891801)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (77917365..77984519)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3846 Neighboring gene glutamate-cysteine ligase, catalytic subunit Neighboring gene predicted gene, 34654 Neighboring gene STARR-seq mESC enhancer starr_24706 Neighboring gene STARR-positive B cell enhancer mm9_chr9:77758381-77758682 Neighboring gene STARR-positive B cell enhancer ABC_E6772 Neighboring gene STARR-positive B cell enhancer ABC_E2906 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:77766361-77766544 Neighboring gene STARR-positive B cell enhancer mm9_chr9:77778672-77778973 Neighboring gene predicted gene, 34771 Neighboring gene predicted gene, 34829 Neighboring gene predicted gene, 39375 Neighboring gene predicted gene, 23609

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables fatty acid elongase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fatty acid elongase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables fatty acid elongase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in fatty acid elongation, monounsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid elongation, monounsaturated fatty acid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid elongation, monounsaturated fatty acid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fatty acid elongation, polyunsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid elongation, polyunsaturated fatty acid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid elongation, polyunsaturated fatty acid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fatty acid elongation, saturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid elongation, saturated fatty acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-chain fatty-acyl-CoA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in unsaturated fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in very long-chain fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in very long-chain fatty acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic tree ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic tree ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    very long chain fatty acid elongase 5
    Names
    3-keto acyl-CoA synthase Elovl5
    ELOVL FA elongase 5
    ELOVL family member 5, elongation of long chain fatty acids
    elongation of very long chain fatty acids protein 5
    fatty acid elongase 1
    homolog of yeast long chain polyunsaturated fatty acid elongation enzyme
    very long chain 3-ketoacyl-CoA synthase 5
    very long chain 3-oxoacyl-CoA synthase 5
    NP_599016.2
    XP_006511463.1
    XP_011241109.2
    XP_030100414.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134255.3NP_599016.2  very long chain fatty acid elongase 5

      See identical proteins and their annotated locations for NP_599016.2

      Status: VALIDATED

      Source sequence(s)
      AK045274, AK162451, CF748582
      Consensus CDS
      CCDS23355.1
      UniProtKB/Swiss-Prot
      Q8BHI7, Q8BLG6, Q8BUE3, Q8R5D3
      UniProtKB/TrEMBL
      X2EXE4
      Related
      ENSMUSP00000034904.8, ENSMUST00000034904.14
      Conserved Domains (1) summary
      pfam01151
      Location:27261
      ELO; GNS1/SUR4 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      77824647..77891801
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244554.2XP_030100414.1  very long chain fatty acid elongase 5 isoform X1

      UniProtKB/TrEMBL
      X2EXE4
      Conserved Domains (1) summary
      pfam01151
      Location:68302
      ELO; GNS1/SUR4 family
    2. XM_011242807.2XP_011241109.2  very long chain fatty acid elongase 5 isoform X3

      Conserved Domains (1) summary
      pfam01151
      Location:68265
      ELO; GNS1/SUR4 family
    3. XM_006511400.1XP_006511463.1  very long chain fatty acid elongase 5 isoform X2

      See identical proteins and their annotated locations for XP_006511463.1

      UniProtKB/Swiss-Prot
      Q8BHI7, Q8BLG6, Q8BUE3, Q8R5D3
      UniProtKB/TrEMBL
      X2EXE4
      Conserved Domains (1) summary
      pfam01151
      Location:27261
      ELO; GNS1/SUR4 family