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    Abhd11 abhydrolase domain containing 11 [ Mus musculus (house mouse) ]

    Gene ID: 68758, updated on 23-Jun-2021

    Summary

    Official Symbol
    Abhd11provided by MGI
    Official Full Name
    abhydrolase domain containing 11provided by MGI
    Primary source
    MGI:MGI:1916008
    See related
    Ensembl:ENSMUSG00000040532
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wbscr; Wbscr21; 1110054D16Rik; A630008N09Rik
    Expression
    Ubiquitous expression in large intestine adult (RPKM 44.7), colon adult (RPKM 41.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Abhd11 in Genome Data Viewer
    Location:
    5; 5 G2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135038006..135041029)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135009152..135012175)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (135485022..135488045)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Williams Beuren syndrome chromosome region 25 (human) Neighboring gene U2 spliceosomal RNA Neighboring gene ribosomal protein S29, pseudogene Neighboring gene abhydrolase domain containing 11, opposite strand Neighboring gene syntaxin 1A (brain) Neighboring gene predicted gene, 25492 Neighboring gene BUD23, rRNA methyltransferase and ribosome maturation factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    protein ABHD11
    Names
    Williams Beuren syndrome chromosome region 21
    Williams-Beuren syndrome chromosomal region 21 protein homolog
    Williams-Beuren syndrome critical region 21
    abhydrolase domain-containing protein 11
    alpha/beta hydrolase domain-containing protein 11

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190437.1NP_001177366.1  protein ABHD11 isoform 2

      See identical proteins and their annotated locations for NP_001177366.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' exon and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC084109
      Consensus CDS
      CCDS51659.1
      UniProtKB/TrEMBL
      D3YYK0
      Related
      ENSMUSP00000106847.2, ENSMUST00000111216.8
      Conserved Domains (2) summary
      pfam00561
      Location:3215
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam12695
      Location:6116
      Abhydrolase_5; Alpha/beta hydrolase family
    2. NM_145215.2NP_660250.1  protein ABHD11 isoform 1

      See identical proteins and their annotated locations for NP_660250.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC084109
      Consensus CDS
      CCDS19730.1
      UniProtKB/Swiss-Prot
      Q8K4F5
      Related
      ENSMUSP00000043041.9, ENSMUST00000046999.12
      Conserved Domains (2) summary
      PRK10673
      Location:61307
      PRK10673; acyl-CoA esterase; Provisional
      pfam12695
      Location:60196
      Abhydrolase_5; Alpha/beta hydrolase family

    RNA

    1. NR_033794.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC084109

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      135038006..135041029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504492.4XP_006504555.1  protein ABHD11 isoform X1

      Conserved Domains (1) summary
      PRK10673
      Location:61267
      PRK10673; esterase

    RNA

    1. XR_003955705.1 RNA Sequence

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