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    Elac2 elaC ribonuclease Z 2 [ Mus musculus (house mouse) ]

    Gene ID: 68626, updated on 23-May-2018

    Summary

    Official Symbol
    Elac2provided by MGI
    Official Full Name
    elaC ribonuclease Z 2provided by MGI
    Primary source
    MGI:MGI:1890496
    See related
    Ensembl:ENSMUSG00000020549 Vega:OTTMUSG00000005902
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hpc2; D11Wsu80e; 1110017O07Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 8.5), ovary adult (RPKM 7.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Elac2 in Genome Data Viewer
    Location:
    11 B3; 11 40.42 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (64979030..65002076)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (64792537..64815578)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30305 Neighboring gene predicted gene 12292 Neighboring gene predicted gene, 40025 Neighboring gene Rho GTPase activating protein 44 Neighboring gene RIKEN cDNA 1700086D15 gene Neighboring gene peroxiredoxin 6 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    tRNA-specific ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    mitochondrial tRNA 3'-trailer cleavage, endonucleolytic IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrial tRNA 3'-trailer cleavage, endonucleolytic ISO
    Inferred from Sequence Orthology
    more info
     
    tRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    mitochondrial nucleoid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    zinc phosphodiesterase ELAC protein 2
    Names
    RNase Z 2
    elaC homolog 2
    elaC homolog protein 2
    putative prostate cancer susceptibility protein
    ribonuclease Z 2
    tRNA 3 endonuclease 2
    tRNase Z 2
    tRNase Z(L)
    NP_075968.2
    XP_006534128.1
    XP_006534129.1
    XP_006534130.1
    XP_006534131.1
    XP_017170220.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362982.1NP_001349911.1  zinc phosphodiesterase ELAC protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL663045
      Conserved Domains (2) summary
      cd07718
      Location:479689
      RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
      cd16296
      Location:52307
      RNaseZ_ELAC2-N-term-like_MBL-fold; Ribonuclease Z, N-terminus of human ELAC2 and related proteins; MBL-fold metallo-hydrolase domain
    2. NM_001362983.1NP_001349912.1  zinc phosphodiesterase ELAC protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL663045
      Conserved Domains (2) summary
      cd07718
      Location:479684
      RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
      cd16296
      Location:52307
      RNaseZ_ELAC2-N-term-like_MBL-fold; Ribonuclease Z, N-terminus of human ELAC2 and related proteins; MBL-fold metallo-hydrolase domain
    3. NM_001362984.1NP_001349913.1  zinc phosphodiesterase ELAC protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL663045
      Conserved Domains (1) summary
      cd07718
      Location:111316
      RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
    4. NM_023479.3NP_075968.2  zinc phosphodiesterase ELAC protein 2 isoform 1

      See identical proteins and their annotated locations for NP_075968.2

      Status: VALIDATED

      Source sequence(s)
      AL663045, BC048235
      Consensus CDS
      CCDS24841.1
      UniProtKB/Swiss-Prot
      Q80Y81
      UniProtKB/TrEMBL
      Q3U0M8
      Related
      ENSMUSP00000071788.5, OTTMUSP00000006092, ENSMUST00000071891.11
      Conserved Domains (3) summary
      COG1234
      Location:478748
      ElaC; Ribonuclease BN, tRNA processing enzyme [Translation, ribosomal structure and biogenesis]
      cd07718
      Location:479684
      RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
      cd16296
      Location:52307
      RNaseZ_ELAC2-N-term-like_MBL-fold; Ribonuclease Z, N-terminus of human ELAC2 and related proteins; MBL-fold metallo-hydrolase domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      64979030..65002076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534065.2XP_006534128.1  zinc phosphodiesterase ELAC protein 2 isoform X1

      Conserved Domains (3) summary
      COG1234
      Location:478753
      ElaC; Ribonuclease BN, tRNA processing enzyme [Translation, ribosomal structure and biogenesis]
      cd07718
      Location:479689
      RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
      cd16296
      Location:52307
      RNaseZ_ELAC2-N-term-like_MBL-fold; Ribonuclease Z, N-terminus of human ELAC2 and related proteins; MBL-fold metallo-hydrolase domain
    2. XM_017314731.1XP_017170220.1  zinc phosphodiesterase ELAC protein 2 isoform X3

    3. XM_006534066.2XP_006534129.1  zinc phosphodiesterase ELAC protein 2 isoform X2

      Conserved Domains (3) summary
      COG1234
      Location:374649
      ElaC; Ribonuclease BN, tRNA processing enzyme [Translation, ribosomal structure and biogenesis]
      cd07718
      Location:375585
      RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
      cl23716
      Location:1203
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
    4. XM_006534067.1XP_006534130.1  zinc phosphodiesterase ELAC protein 2 isoform X4

      Conserved Domains (2) summary
      COG1234
      Location:110385
      ElaC; Ribonuclease BN, tRNA processing enzyme [Translation, ribosomal structure and biogenesis]
      cd07718
      Location:111321
      RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
    5. XM_006534068.1XP_006534131.1  zinc phosphodiesterase ELAC protein 2 isoform X5

      Conserved Domains (2) summary
      COG1234
      Location:110380
      ElaC; Ribonuclease BN, tRNA processing enzyme [Translation, ribosomal structure and biogenesis]
      cd07718
      Location:111316
      RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
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