Format

Send to:

Choose Destination
    • Showing Current items.

    Rtn4 reticulon 4 [ Mus musculus (house mouse) ]

    Gene ID: 68585, updated on 22-Aug-2021

    Summary

    Official Symbol
    Rtn4provided by MGI
    Official Full Name
    reticulon 4provided by MGI
    Primary source
    MGI:MGI:1915835
    See related
    Ensembl:ENSMUSG00000020458
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    N; No; ASY; NgA; Nog; NOGO; NSP-CL; Nogo-A; Nogo-B; Nogo-C; AA407876; AA409940; AA960376; mKIAA0886; mKIAA4153; 1110020G17Rik; C130026I10Rik
    Expression
    Broad expression in CNS E18 (RPKM 70.4), frontal lobe adult (RPKM 55.5) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rtn4 in Genome Data Viewer
    Location:
    11; 11 A3.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (29642898..29694414)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (29692898..29744414)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (29592898..29644414)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12092 Neighboring gene predicted gene, 53675 Neighboring gene apurinic/apyrimidinic endonuclease 2 pseudogene Neighboring gene echinoderm microtubule associated protein like 6 Neighboring gene predicted gene, 39671 Neighboring gene fem-1 homolog A like Neighboring gene 60S ribosomal protein L23a pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4153

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axonal fasciculation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axonal fasciculation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within blastocyst formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cardiac epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration involved in vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular sphingolipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in central nervous system vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cerebral cortex radial glia-guided migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endoplasmic reticulum organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum tubular network formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum tubular network membrane organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum tubular network organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukocyte migration involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of axon extension ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of dendrite extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of formation of growth cone in injured axon IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron projection regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within nervous system development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nuclear pore complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERBB3 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Rac protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of artery morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of collateral sprouting of injured axon IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of dopamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hepatocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of macrophage cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of macrophage migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mammary gland epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of toll-like receptor 9 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to lysosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of branching morphogenesis of a nerve IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of branching morphogenesis of a nerve ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum tubular network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum tubular network membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in myelin sheath ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    reticulon-4
    Names
    neurite outgrowth inhibitor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024226.4NP_077188.1  reticulon-4 isoform C

      See identical proteins and their annotated locations for NP_077188.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses a different segment for its 5' end, compared to variant 1. The resulting protein (isoform C) has a shorter and distinct N-terminus when it is compared to isoform A.
      Source sequence(s)
      AK034902, BU698622, BU848611, BY251875
      Consensus CDS
      CCDS24503.1
      UniProtKB/Swiss-Prot
      Q99P72
      UniProtKB/TrEMBL
      Q78NS1
      Related
      ENSMUSP00000053754.5, ENSMUST00000060992.6
      Conserved Domains (1) summary
      pfam02453
      Location:12176
      Reticulon; Reticulon
    2. NM_194051.3NP_918940.1  reticulon-4 isoform D

      See identical proteins and their annotated locations for NP_918940.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses a different segment for its 5' end, compared to variant 1. The resulting protein (isoform D) has a shorter and distinct N-terminus when it is compared to isoform A.
      Source sequence(s)
      AK034902, AL929371, BC032272, BU698622
      Consensus CDS
      CCDS24502.1
      UniProtKB/Swiss-Prot
      Q99P72
      Related
      ENSMUSP00000099905.2, ENSMUST00000102841.8
      Conserved Domains (1) summary
      pfam02453
      Location:8591023
      Reticulon; Reticulon
    3. NM_194052.3NP_918941.1  reticulon-4 isoform B1

      See identical proteins and their annotated locations for NP_918941.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks one alternate exon in the coding region, compared to variant 1. The resulting protein (isoform B1) is shorter when it is compared to isoform A.
      Source sequence(s)
      AK034902, AL929371, BU698622
      Consensus CDS
      CCDS24499.1
      UniProtKB/TrEMBL
      Q8BH78
      Related
      ENSMUSP00000077875.5, ENSMUST00000078830.11
      Conserved Domains (1) summary
      pfam02453
      Location:169333
      Reticulon; Reticulon
    4. NM_194053.3NP_918942.1  reticulon-4 isoform B2

      See identical proteins and their annotated locations for NP_918942.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate exons in the coding region, compared to variant 1. The resulting protein (isoform B2) is shorter when it is compared to isoform A.
      Source sequence(s)
      AK034902, AL929371, BU698622
      Consensus CDS
      CCDS24500.1
      UniProtKB/TrEMBL
      Q8BHF5
      Related
      ENSMUSP00000099906.4, ENSMUST00000102842.10
      Conserved Domains (1) summary
      pfam02453
      Location:188352
      Reticulon; Reticulon
    5. NM_194054.3NP_918943.1  reticulon-4 isoform A

      See identical proteins and their annotated locations for NP_918943.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform A).
      Source sequence(s)
      AK034902, AL929371, BC032272, BU698622
      Consensus CDS
      CCDS24501.1
      UniProtKB/Swiss-Prot
      Q99P72
      Related
      ENSMUSP00000099907.4, ENSMUST00000102843.10
      Conserved Domains (1) summary
      pfam02453
      Location:9751139
      Reticulon; Reticulon

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      29642898..29694414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center