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    Lamtor5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 [ Mus musculus (house mouse) ]

    Gene ID: 68576, updated on 16-Oct-2021

    Summary

    Official Symbol
    Lamtor5provided by MGI
    Official Full Name
    late endosomal/lysosomal adaptor, MAPK and MTOR activator 5provided by MGI
    Primary source
    MGI:MGI:1915826
    See related
    Ensembl:ENSMUSG00000087260
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    XIP; Hbxip; 1110003H18Rik
    Expression
    Ubiquitous expression in kidney adult (RPKM 71.3), large intestine adult (RPKM 37.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Lamtor5 in Genome Data Viewer
    Location:
    3; 3 F2.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (107186174..107191398)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (107278858..107284082)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (107081776..107087000)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene chymosin Neighboring gene RIKEN cDNA A630076J17 gene Neighboring gene prokineticin 1 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 4 Neighboring gene RNA binding motif protein 15 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to amino acid stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Ragulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Ragulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ragulator complex protein LAMTOR5
    Names
    HBV X-interacting protein homolog
    HBX-interacting protein homolog
    hepatitis B virus X-interacting protein homolog
    hepatitis B virus x interacting protein
    late endosomal/lysosomal adaptor and MAPK and MTOR activator 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026774.2NP_081050.2  ragulator complex protein LAMTOR5

      See identical proteins and their annotated locations for NP_081050.2

      Status: VALIDATED

      Source sequence(s)
      AI552736, BC028547
      Consensus CDS
      CCDS51042.1
      UniProtKB/Swiss-Prot
      Q9D1L9
      UniProtKB/TrEMBL
      G3UW70
      Related
      ENSMUSP00000129012.2, ENSMUST00000145735.6
      Conserved Domains (1) summary
      pfam16672
      Location:55142
      LAMTOR5; Ragulator complex protein LAMTOR5

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      107186174..107191398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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