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    Ankra2 ankyrin repeat, family A (RFXANK-like), 2 [ Mus musculus (house mouse) ]

    Gene ID: 68558, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ankra2provided by MGI
    Official Full Name
    ankyrin repeat, family A (RFXANK-like), 2provided by MGI
    Primary source
    MGI:MGI:1915808
    See related
    Ensembl:ENSMUSG00000021661
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ankra; 1110004M18Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 19.9), CNS E14 (RPKM 15.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ankra2 in Genome Data Viewer
    Location:
    13; 13 D1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (98263076..98274754)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (99033197..99043868)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor (GEF) 28 Neighboring gene predicted gene, 34469 Neighboring gene UTP15 small subunit processome component Neighboring gene predicted gene 21976 Neighboring gene basic transcription factor 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC90650

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    histone deacetylase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    regulation of protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with 3M complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ankyrin repeat family A protein 2
    Names
    RFXANK-like protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271388.1NP_001258317.1  ankyrin repeat family A protein 2 isoform a

      See identical proteins and their annotated locations for NP_001258317.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
      Source sequence(s)
      AC123056, AK139343, AK161446, BE952624
      Consensus CDS
      CCDS70493.1
      UniProtKB/TrEMBL
      Q3UTL3, Q6NZJ1
      Related
      ENSMUSP00000122701.1, ENSMUST00000123924.7
      Conserved Domains (3) summary
      cd00204
      Location:175292
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:185276
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:180211
      ANK; ANK repeat [structural motif]
    2. NM_001271389.1NP_001258318.1  ankyrin repeat family A protein 2 isoform b

      See identical proteins and their annotated locations for NP_001258318.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and has an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is longer and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK161446, BC079615
      Consensus CDS
      CCDS70492.1
      UniProtKB/TrEMBL
      Q6AXE4
      Related
      ENSMUSP00000117508.1, ENSMUST00000150352.2
      Conserved Domains (3) summary
      cd00204
      Location:175292
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:185276
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:180211
      ANK; ANK repeat [structural motif]
    3. NM_001271390.1NP_001258319.1  ankyrin repeat family A protein 2 isoform c

      See identical proteins and their annotated locations for NP_001258319.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate in-frame downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a.
      Source sequence(s)
      AK081695, AK161446, BE952624
      Consensus CDS
      CCDS70494.1
      UniProtKB/TrEMBL
      Q8C4M9
      Related
      ENSMUSP00000088915.3, ENSMUST00000091356.10
      Conserved Domains (4) summary
      COG0666
      Location:142
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:15132
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:25116
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:2051
      ANK; ANK repeat [structural motif]
    4. NM_001271391.1NP_001258320.1  ankyrin repeat family A protein 2 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains multiple differences in the UTRs and coding region, compared to variant 1. These differences result in initiation of translation at an alternate in-frame downstream start codon, compared to variant 1. The encoded isoform (e) has a shorter N-terminus and a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK003438, AK161446, BE952624, BF730624
      UniProtKB/TrEMBL
      A0A286YDH7
      Related
      ENSMUSP00000153417.1, ENSMUST00000226100.1
      Conserved Domains (2) summary
      cd00204
      Location:15135
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:2051
      ANK; ANK repeat [structural motif]
    5. NM_001271392.1NP_001258321.1  ankyrin repeat family A protein 2 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains multiple differences in the UTRs and coding region, compared to variant 1. These differences result in initiation of translation at an alternate in-frame downstream start codon, compared to variant 1. The encoded isoform (f) has a shorter N-terminus and a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK003438, AK161446, BE952624
      UniProtKB/TrEMBL
      D3Z4I1
      Related
      ENSMUSP00000116590.2, ENSMUST00000150916.8
      Conserved Domains (4) summary
      COG0666
      Location:142
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:15132
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:25116
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:2051
      ANK; ANK repeat [structural motif]
    6. NM_023472.2NP_075961.1  ankyrin repeat family A protein 2 isoform d

      See identical proteins and their annotated locations for NP_075961.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and has an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (d) is longer and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK161446, BC079615, BE952624, BF730624
      Consensus CDS
      CCDS26713.1
      UniProtKB/Swiss-Prot
      Q99PE2
      UniProtKB/TrEMBL
      Q6AXE4
      Related
      ENSMUSP00000022164.8, ENSMUST00000022164.15
      Conserved Domains (3) summary
      cd00204
      Location:175295
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:185276
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:180211
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      98263076..98274754
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315580.1XP_017171069.1  ankyrin repeat family A protein 2 isoform X1

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