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    Sgo2a shugoshin 2A [ Mus musculus (house mouse) ]

    Gene ID: 68549, updated on 13-Feb-2024

    Summary

    Official Symbol
    Sgo2aprovided by MGI
    Official Full Name
    shugoshin 2Aprovided by MGI
    Primary source
    MGI:MGI:1098767
    See related
    Ensembl:ENSMUSG00000026039 AllianceGenome:MGI:1098767
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sgol2; Sgol2a; Tripin; D1Ertd8e; 1110007N04Rik; 4932411A20Rik; 5730576N04Rik
    Summary
    Acts upstream of or within meiotic nuclear division; positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric; and protein localization. Located in kinetochore. Is expressed in nervous system and oocyte. Orthologous to human SGO2 (shugoshin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E11.5 (RPKM 7.1), placenta adult (RPKM 4.8) and 12 other tissues See more
    Orthologs
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    Genomic context

    See Sgo2a in Genome Data Viewer
    Location:
    1 C1.3; 1 28.86 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58024499..58065436)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (57985340..58026277)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated, serine-rich 2-like Neighboring gene STARR-seq mESC enhancer starr_00998 Neighboring gene predicted gene, 57576 Neighboring gene potassium channel tetramerisation domain containing 18 Neighboring gene STARR-positive B cell enhancer ABC_E7730 Neighboring gene STARR-seq mESC enhancer starr_01001 Neighboring gene STARR-seq mESC enhancer starr_01003 Neighboring gene aldehyde oxidase 1 Neighboring gene STARR-seq mESC enhancer starr_01004 Neighboring gene STARR-seq mESC enhancer starr_01005 Neighboring gene predicted gene, 39643 Neighboring gene aldehyde oxidase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1)  1 citation
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of mitotic cohesin complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    shugoshin 2
    Names
    sgo2
    shugoshin-like 2
    shugoshin-like 2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177867.1NP_001171338.1  shugoshin 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a few of 5' exons but has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1.
      Source sequence(s)
      BC052742, CN716821
      UniProtKB/Swiss-Prot
      Q7TSY8
      Conserved Domains (1) summary
      pfam05539
      Location:35228
      Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G
    2. NM_199007.2NP_950172.1  shugoshin 2 isoform 1

      See identical proteins and their annotated locations for NP_950172.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK042448, AK138621, BC052742
      Consensus CDS
      CCDS35574.1
      UniProtKB/Swiss-Prot
      Q7TSY8, Q811I4, Q8C9C4, Q8CGJ4, Q9CS55
      Related
      ENSMUSP00000027202.9, ENSMUST00000027202.9
      Conserved Domains (1) summary
      pfam05539
      Location:135328
      Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      58024499..58065436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)