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    Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase [ Mus musculus (house mouse) ]

    Gene ID: 68501, updated on 23-Jun-2021

    Summary

    Official Symbol
    Nsmce2provided by MGI
    Official Full Name
    NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligaseprovided by MGI
    Primary source
    MGI:MGI:1915751
    See related
    Ensembl:ENSMUSG00000059586
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI661537; 1110014D18Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.9), placenta adult (RPKM 4.5) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Nsmce2 in Genome Data Viewer
    Location:
    15; 15 D1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (59246047..59473538)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (59374198..59601689)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (59205753..59433239)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene squalene epoxidase Neighboring gene WASH complex subunit 5 Neighboring gene predicted gene, 36677 Neighboring gene tribbles pseudokinase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SUMO ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Smc5-Smc6 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Smc5-Smc6 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 SUMO-protein ligase NSE2
    Names
    E3 SUMO-protein transferase NSE2
    MMS21 homolog
    non-SMC element 2 homolog (MMS21, S. cerevisiae)
    non-structural maintenance of chromosomes element 2 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164604.1NP_001158076.1  E3 SUMO-protein ligase NSE2 isoform 2

      See identical proteins and their annotated locations for NP_001158076.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate exon, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK051277, BE991399, DV057668
      Consensus CDS
      CCDS49611.1
      UniProtKB/Swiss-Prot
      Q91VT1
      Related
      ENSMUSP00000128893.2, ENSMUST00000168722.3
    2. NM_001374768.1NP_001361697.1  E3 SUMO-protein ligase NSE2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC107764, AC113269, AC161172
      Consensus CDS
      CCDS88769.1
      Related
      ENSMUSP00000154811.2, ENSMUST00000227173.2
      Conserved Domains (1) summary
      cd16651
      Location:193262
      SPL-RING_NSE2; SPL-RING finger found in E3 SUMO-protein ligase NSE2 and similar proteins
    3. NM_026746.3NP_081022.2  E3 SUMO-protein ligase NSE2 isoform 1

      See identical proteins and their annotated locations for NP_081022.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (1).
      Source sequence(s)
      AK003685, AW489283, DV057668
      Consensus CDS
      CCDS27498.1
      UniProtKB/Swiss-Prot
      Q91VT1
      Related
      ENSMUSP00000078641.4, ENSMUST00000079703.11
      Conserved Domains (1) summary
      pfam11789
      Location:156216
      zf-Nse; Zinc-finger of the MIZ type in Nse subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      59246047..59473538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316737.3XP_017172226.1  E3 SUMO-protein ligase NSE2 isoform X2

      Conserved Domains (1) summary
      cl17238
      Location:182231
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    2. XM_030248724.2XP_030104584.1  E3 SUMO-protein ligase NSE2 isoform X3

      Conserved Domains (1) summary
      cl17238
      Location:156205
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    3. XM_006521317.5XP_006521380.1  E3 SUMO-protein ligase NSE2 isoform X1

      Conserved Domains (1) summary
      cd16651
      Location:192261
      SPL-RING_NSE2; SPL-RING finger found in E3 SUMO-protein ligase NSE2 and similar proteins
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