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    Arel1 apoptosis resistant E3 ubiquitin protein ligase 1 [ Mus musculus (house mouse) ]

    Gene ID: 68497, updated on 21-Apr-2024

    Summary

    Official Symbol
    Arel1provided by MGI
    Official Full Name
    apoptosis resistant E3 ubiquitin protein ligase 1provided by MGI
    Primary source
    MGI:MGI:1915747
    See related
    Ensembl:ENSMUSG00000042350 AllianceGenome:MGI:1915747
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110018G07Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Involved in protein ubiquitination; regulation of inflammatory response; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human AREL1 (apoptosis resistant E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 22.2), CNS E18 (RPKM 18.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    Location:
    12 D1; 12 39.46 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84964914..85017674, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84918140..84970878, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene iron-sulfur cluster assembly 2 Neighboring gene latent transforming growth factor beta binding protein 2 Neighboring gene STARR-seq mESC enhancer starr_32756 Neighboring gene STARR-seq mESC enhancer starr_32757 Neighboring gene RIKEN cDNA D030025P21 gene Neighboring gene STARR-positive B cell enhancer ABC_E7160 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:86311736-86311923 Neighboring gene STARR-positive B cell enhancer ABC_E1446 Neighboring gene STARR-seq mESC enhancer starr_32760 Neighboring gene FCF1 rRNA processing protein Neighboring gene STARR-seq mESC enhancer starr_32761 Neighboring gene YLP motif containing 1 Neighboring gene STARR-seq mESC enhancer starr_32762

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • Kiaa0317, mKIAA0317

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K33-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    apoptosis-resistant E3 ubiquitin protein ligase 1
    Names
    apoptosis-resistant HECT-type E3 ubiquitin transferase 1
    NP_001351118.1
    NP_001351119.1
    NP_835166.3
    XP_006516254.1
    XP_030102751.1
    XP_030102752.1
    XP_036013493.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364189.1NP_001351118.1  apoptosis-resistant E3 ubiquitin protein ligase 1

      Status: VALIDATED

      Source sequence(s)
      CR974585
      Consensus CDS
      CCDS26051.1
      UniProtKB/Swiss-Prot
      Q6P9Q1, Q80YC4, Q8C5W5, Q8CHG5
      UniProtKB/TrEMBL
      Q3U3Y1
      Conserved Domains (2) summary
      cd00078
      Location:464821
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:56154
      Filamin; Filamin/ABP280 repeat
    2. NM_001364190.1NP_001351119.1  apoptosis-resistant E3 ubiquitin protein ligase 1

      Status: VALIDATED

      Source sequence(s)
      AK077015, AK147491, CR974585
      Consensus CDS
      CCDS26051.1
      UniProtKB/Swiss-Prot
      Q6P9Q1, Q80YC4, Q8C5W5, Q8CHG5
      UniProtKB/TrEMBL
      Q3U3Y1
      Conserved Domains (2) summary
      cd00078
      Location:464821
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:56154
      Filamin; Filamin/ABP280 repeat
    3. NM_178065.5NP_835166.3  apoptosis-resistant E3 ubiquitin protein ligase 1

      See identical proteins and their annotated locations for NP_835166.3

      Status: VALIDATED

      Source sequence(s)
      AW045956, BC060658, BC079590, CJ128427
      Consensus CDS
      CCDS26051.1
      UniProtKB/Swiss-Prot
      Q6P9Q1, Q80YC4, Q8C5W5, Q8CHG5
      UniProtKB/TrEMBL
      Q3U3Y1
      Related
      ENSMUSP00000048780.8, ENSMUST00000043169.14
      Conserved Domains (2) summary
      cd00078
      Location:464821
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:56154
      Filamin; Filamin/ABP280 repeat

    RNA

    1. NR_157097.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CR974585
      Related
      ENSMUST00000163231.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      84964914..85017674 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516191.5XP_006516254.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X2

      UniProtKB/TrEMBL
      Q3U3Y1
      Conserved Domains (2) summary
      cd00078
      Location:454811
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:56143
      Filamin; Filamin/ABP280 repeat
    2. XM_030246892.2XP_030102752.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X2

      UniProtKB/TrEMBL
      Q3U3Y1
      Conserved Domains (2) summary
      cd00078
      Location:454811
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:56143
      Filamin; Filamin/ABP280 repeat
    3. XM_036157600.1XP_036013493.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6P9Q1, Q80YC4, Q8C5W5, Q8CHG5
      UniProtKB/TrEMBL
      Q3U3Y1
      Conserved Domains (2) summary
      cd00078
      Location:464821
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:56154
      Filamin; Filamin/ABP280 repeat
    4. XM_030246891.1XP_030102751.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6P9Q1, Q80YC4, Q8C5W5, Q8CHG5
      UniProtKB/TrEMBL
      Q3U3Y1
      Conserved Domains (2) summary
      cd00078
      Location:464821
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:56154
      Filamin; Filamin/ABP280 repeat

    RNA

    1. XR_872717.3 RNA Sequence