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    Arel1 apoptosis resistant E3 ubiquitin protein ligase 1 [ Mus musculus (house mouse) ]

    Gene ID: 68497, updated on 31-Jan-2019

    Summary

    Official Symbol
    Arel1provided by MGI
    Official Full Name
    apoptosis resistant E3 ubiquitin protein ligase 1provided by MGI
    Primary source
    MGI:MGI:1915747
    See related
    Ensembl:ENSMUSG00000042350
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI649076; AW610792; 1110018G07Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 22.2), CNS E18 (RPKM 18.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Arel1 in Genome Data Viewer
    Location:
    12; 12 D1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (84918148..84970886, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (86259098..86311836, complement)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene iron-sulfur cluster assembly 2 Neighboring gene latent transforming growth factor beta binding protein 2 Neighboring gene RIKEN cDNA D030025P21 gene Neighboring gene FCF1 rRNA processing protein Neighboring gene YLP motif containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Chemically induced (ENU) (1) 

    General gene information

    Markers

    Homology

    Clone Names

    • Kiaa0317, mKIAA0317

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    apoptosis-resistant E3 ubiquitin protein ligase 1
    Names
    apoptosis-resistant HECT-type E3 ubiquitin transferase 1
    NP_835166.3
    XP_006516252.1
    XP_006516253.1
    XP_006516254.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364189.1NP_001351118.1  apoptosis-resistant E3 ubiquitin protein ligase 1

      Status: VALIDATED

      Source sequence(s)
      CR974585
      Conserved Domains (2) summary
      cd00078
      Location:464821
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:56154
      Filamin; Filamin/ABP280 repeat
    2. NM_001364190.1NP_001351119.1  apoptosis-resistant E3 ubiquitin protein ligase 1

      Status: VALIDATED

      Source sequence(s)
      AK077015, AK147491, CR974585
      Conserved Domains (2) summary
      cd00078
      Location:464821
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:56154
      Filamin; Filamin/ABP280 repeat
    3. NM_178065.5NP_835166.3  apoptosis-resistant E3 ubiquitin protein ligase 1

      See identical proteins and their annotated locations for NP_835166.3

      Status: VALIDATED

      Source sequence(s)
      AW045956, BC060658, BC079590, CJ128427
      Consensus CDS
      CCDS26051.1
      UniProtKB/Swiss-Prot
      Q8CHG5
      Related
      ENSMUSP00000048780.7, ENSMUST00000043169.13
      Conserved Domains (2) summary
      cd00078
      Location:464821
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:56154
      Filamin; Filamin/ABP280 repeat

    RNA

    1. NR_157097.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CR974585

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      84918148..84970886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516189.3XP_006516252.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8CHG5
      Conserved Domains (2) summary
      cd00078
      Location:464821
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:56154
      Filamin; Filamin/ABP280 repeat
    2. XM_006516191.3XP_006516254.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X2

      Conserved Domains (3) summary
      smart00119
      Location:476810
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:454811
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:56144
      Filamin; Filamin/ABP280 repeat
    3. XM_006516190.2XP_006516253.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8CHG5
      Conserved Domains (2) summary
      cd00078
      Location:464821
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:56154
      Filamin; Filamin/ABP280 repeat

    RNA

    1. XR_872717.2 RNA Sequence

      Related
      ENSMUST00000163231.7
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