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    Rmnd5a required for meiotic nuclear division 5 homolog A [ Mus musculus (house mouse) ]

    Gene ID: 68477, updated on 26-Sep-2022

    Summary

    Official Symbol
    Rmnd5aprovided by MGI
    Official Full Name
    required for meiotic nuclear division 5 homolog Aprovided by MGI
    Primary source
    MGI:MGI:1915727
    See related
    Ensembl:ENSMUSG00000002222 AllianceGenome:MGI:1915727
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gid2; MTA.D02.090; 1110007A06Rik
    Summary
    Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in nucleoplasm. Predicted to be part of GID complex and ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human RMND5A (required for meiotic nuclear division 5 homolog A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 62.2), cerebellum adult (RPKM 22.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rmnd5a in Genome Data Viewer
    Location:
    6; 6 C1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (71365618..71417621, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (71388634..71440637, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene Cd8 alpha DNase I hypersensitive cluster CIII Neighboring gene Cd8 alpha DNase I hypersensitive cluster CII Neighboring gene CD8 antigen, alpha chain Neighboring gene predicted gene, 30582 Neighboring gene ring finger protein 103

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC59617

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of GID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RMND5A
    Names
    protein RMD5 homolog A
    NP_001342674.1
    NP_077250.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355745.1NP_001342674.1  E3 ubiquitin-protein ligase RMND5A

      Status: VALIDATED

      Source sequence(s)
      AC154001, AC160090
      Consensus CDS
      CCDS20231.1
      UniProtKB/Swiss-Prot
      Q3UFE2
      UniProtKB/TrEMBL
      A0A6P7R4I1, A0A8C6MT57
      Conserved Domains (2) summary
      COG5109
      Location:17391
      COG5109; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      pfam10607
      Location:153297
      CLTH; CTLH/CRA C-terminal to LisH motif domain
    2. NM_024288.2NP_077250.2  E3 ubiquitin-protein ligase RMND5A

      See identical proteins and their annotated locations for NP_077250.2

      Status: VALIDATED

      Source sequence(s)
      AC160090, AK148556, AK164384, CF748545
      Consensus CDS
      CCDS20231.1
      UniProtKB/Swiss-Prot
      Q3UFE2, Q80YQ8
      UniProtKB/TrEMBL
      A0A6P7R4I1, A0A8C6MT57
      Related
      ENSMUSP00000002292.9, ENSMUST00000002292.15
      Conserved Domains (2) summary
      COG5109
      Location:17391
      COG5109; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      pfam10607
      Location:153297
      CLTH; CTLH/CRA C-terminal to LisH motif domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      71365618..71417621 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)