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    Tbc1d10b TBC1 domain family, member 10b [ Mus musculus (house mouse) ]

    Gene ID: 68449, updated on 23-Nov-2023


    Official Symbol
    Tbc1d10bprovided by MGI
    Official Full Name
    TBC1 domain family, member 10bprovided by MGI
    Primary source
    See related
    Ensembl:ENSMUSG00000042492 AllianceGenome:MGI:1915699
    Gene type
    protein coding
    RefSeq status
    Mus musculus
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity; intracellular protein transport; and retrograde transport, endosome to Golgi. Predicted to be located in plasma membrane. Orthologous to human TBC1D10B (TBC1 domain family member 10B). [provided by Alliance of Genome Resources, Apr 2022]
    Ubiquitous expression in thymus adult (RPKM 22.9), ovary adult (RPKM 16.8) and 28 other tissues See more
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    Genomic context

    See Tbc1d10b in Genome Data Viewer
    7 F3; 7 69.38 cM
    Exon count:
    Annotation release Status Assembly Chr Location
    RS_2023_04 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126796631..126807640, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127197459..127208468, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene TAR (HIV) RNA binding protein 2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134332123-134332276 Neighboring gene CD2 cytoplasmic tail binding protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134353944-134354145 Neighboring gene myosin light chain, phosphorylatable, fast skeletal muscle Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134361531-134361732 Neighboring gene septin 1 Neighboring gene predicted gene 4532 Neighboring gene zinc finger protein 553

    Genomic regions, transcripts, and products


    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a



    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information


    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    involved_in regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info

    General protein information

    Preferred Names
    TBC1 domain family member 10B
    protein wz3-85

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144522.5NP_653105.3  TBC1 domain family member 10B

      See identical proteins and their annotated locations for NP_653105.3

      Status: VALIDATED

      Source sequence(s)
      AC122537, AK047320
      Consensus CDS
      Q6GQW9, Q6PIZ5, Q8BHL3, Q91XR3
      ENSMUSP00000113307.2, ENSMUST00000120705.3
      Conserved Domains (2) summary
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      PRK12323; DNA polymerase III subunit gamma/tau

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J


    1. NC_000073.7 Reference GRCm39 C57BL/6J

      126796631..126807640 complement
      GenBank, FASTA, Sequence Viewer (Graphics)