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    Apoo apolipoprotein O [ Mus musculus (house mouse) ]

    Gene ID: 68316, updated on 23-Jun-2021

    Summary

    Official Symbol
    Apooprovided by MGI
    Official Full Name
    apolipoprotein Oprovided by MGI
    Primary source
    MGI:MGI:1915566
    See related
    Ensembl:ENSMUSG00000079508
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mico; Micos26; 0610008C08Rik; 1110019O03Rik
    Expression
    Ubiquitous expression in heart adult (RPKM 13.3), kidney adult (RPKM 6.6) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Apoo in Genome Data Viewer
    Location:
    X; X C3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (93410615..93460699)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (94367010..94417093)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (91612449..91662429)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene cell division cycle associated 5 pseudogene Neighboring gene family with sequence similarity 90, member A1B Neighboring gene M phase phosphoprotein 6 pseudogene Neighboring gene predicted gene 14827 Neighboring gene thrombospondin, type I, domain containing 7B pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC130105, MGC130106

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cristae formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cristae formation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of MICOS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of MICOS complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    MICOS complex subunit Mic26
    Names
    MICOS complex subunit Mic23

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199337.1NP_001186266.1  MICOS complex subunit Mic26 isoform 2

      See identical proteins and their annotated locations for NP_001186266.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different segment for its 5' end which utilizes an upstream start codon, compared to variant 1. The resulting protein (isoform 2) is longer when it is compared to isoform 1.
      Source sequence(s)
      AK002320, DV662362
      Consensus CDS
      CCDS57769.1
      UniProtKB/Swiss-Prot
      Q9DCZ4
      Related
      ENSMUSP00000109530.3, ENSMUST00000113897.9
      Conserved Domains (1) summary
      pfam09769
      Location:55191
      ApoO; Apolipoprotein O
    2. NM_001199338.1NP_001186267.1  MICOS complex subunit Mic26 isoform 3

      See identical proteins and their annotated locations for NP_001186267.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains a different segment for its 5' end which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus when it is compared to isoform 1. Variants 3 and 4 encode the same protein.
      Source sequence(s)
      AK002320, AK003831, DV662362
      Consensus CDS
      CCDS57770.1
      UniProtKB/Swiss-Prot
      Q9DCZ4
      Related
      ENSMUSP00000109529.2, ENSMUST00000113896.8
      Conserved Domains (1) summary
      pfam09769
      Location:7143
      ApoO; Apolipoprotein O
    3. NM_001199339.1NP_001186268.1  MICOS complex subunit Mic26 isoform 3

      See identical proteins and their annotated locations for NP_001186268.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains a different segment for its 5' end which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus when it is compared to isoform 1. Variants 3 and 4 encode the same protein.
      Source sequence(s)
      AK002320, BC016557
      Consensus CDS
      CCDS57770.1
      UniProtKB/Swiss-Prot
      Q9DCZ4
      Related
      ENSMUSP00000109528.2, ENSMUST00000113895.2
      Conserved Domains (1) summary
      pfam09769
      Location:7143
      ApoO; Apolipoprotein O
    4. NM_026673.4NP_080949.2  MICOS complex subunit Mic26 isoform 1 precursor

      See identical proteins and their annotated locations for NP_080949.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the more frequently occurring transcript. Variant 1 encodes isoform 1.
      Source sequence(s)
      BU534555, CB595096, DV662362, EL957008
      Consensus CDS
      CCDS53136.1
      UniProtKB/Swiss-Prot
      Q9DCZ4
      Related
      ENSMUSP00000109531.2, ENSMUST00000113898.8
      Conserved Domains (1) summary
      pfam09769
      Location:41177
      ApoO; Apolipoprotein O

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      93410615..93460699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247666.3XP_011245968.1  MICOS complex subunit Mic26 isoform X1

      Conserved Domains (1) summary
      pfam09769
      Location:54177
      ApoO; Apolipoprotein O
    2. XM_011247668.4XP_011245970.1  MICOS complex subunit Mic26 isoform X2

      See identical proteins and their annotated locations for XP_011245970.1

      Conserved Domains (1) summary
      pfam09769
      Location:20143
      ApoO; Apolipoprotein O
    3. XM_011247667.4XP_011245969.1  MICOS complex subunit Mic26 isoform X2

      See identical proteins and their annotated locations for XP_011245969.1

      Conserved Domains (1) summary
      pfam09769
      Location:20143
      ApoO; Apolipoprotein O
    4. XM_011247669.3XP_011245971.1  MICOS complex subunit Mic26 isoform X2

      See identical proteins and their annotated locations for XP_011245971.1

      Conserved Domains (1) summary
      pfam09769
      Location:20143
      ApoO; Apolipoprotein O
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