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    Spindoc spindlin interactor and repressor of chromatin binding [ Mus musculus (house mouse) ]

    Gene ID: 68229, updated on 18-Sep-2024

    Summary

    Official Symbol
    Spindocprovided by MGI
    Official Full Name
    spindlin interactor and repressor of chromatin bindingprovided by MGI
    Primary source
    MGI:MGI:2147611
    See related
    Ensembl:ENSMUSG00000024970 AllianceGenome:MGI:2147611
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SPIN-DOC; 1700105P06Rik
    Summary
    Involved in negative regulation of transcription, DNA-templated. Orthologous to human SPINDOC (spindlin interactor and repressor of chromatin binding). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 16.5), thymus adult (RPKM 10.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Spindoc in Genome Data Viewer
    Location:
    19 A; 19 5.32 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (7333828..7364491, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (7356463..7384302, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene REST corepressor 2 Neighboring gene MAP/microtubule affinity regulating kinase 2 Neighboring gene predicted gene 17227 Neighboring gene STARR-seq mESC enhancer starr_45463 Neighboring gene STARR-seq mESC enhancer starr_45464 Neighboring gene STARR-seq mESC enhancer starr_45465 Neighboring gene RIKEN cDNA 1700105P06 gene Neighboring gene STARR-positive B cell enhancer ABC_E3240 Neighboring gene RAB11B, member RAS oncogene family, pseudogene 2 Neighboring gene predicted gene, 18842

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein ADP-ribosylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in site of DNA damage ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    spindlin interactor and repressor of chromatin-binding protein
    Names
    SPIN1-docking protein
    uncharacterized protein C11orf84 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033139.4NP_001028311.2  spindlin interactor and repressor of chromatin-binding protein isoform 1

      See identical proteins and their annotated locations for NP_001028311.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC129188
      Consensus CDS
      CCDS29523.1
      UniProtKB/Swiss-Prot
      Q05AH6, Q3TI49, Q3TQH2
      Related
      ENSMUSP00000025924.3, ENSMUST00000025924.4
    2. NM_001167831.2NP_001161303.1  spindlin interactor and repressor of chromatin-binding protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC129188
      UniProtKB/TrEMBL
      A0A494BBB2
      Related
      ENSMUST00000236817.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      7333828..7364491 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251065.2XP_030106925.1  spindlin interactor and repressor of chromatin-binding protein isoform X3

      Conserved Domains (1) summary
      pfam18658
      Location:71135
      zf-C2H2_12; Zinc-finger C2H2-type
    2. XM_011247332.4XP_011245634.1  spindlin interactor and repressor of chromatin-binding protein isoform X2

      Conserved Domains (1) summary
      pfam18658
      Location:110174
      zf-C2H2_12; Zinc-finger C2H2-type
    3. XM_011247331.4XP_011245633.1  spindlin interactor and repressor of chromatin-binding protein isoform X1

      Conserved Domains (1) summary
      pfam18658
      Location:110174
      zf-C2H2_12; Zinc-finger C2H2-type

    RNA

    1. XR_003952811.2 RNA Sequence