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    Spire1 spire type actin nucleation factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 68166, updated on 23-Jun-2021

    Summary

    Official Symbol
    Spire1provided by MGI
    Official Full Name
    spire type actin nucleation factor 1provided by MGI
    Primary source
    MGI:MGI:1915416
    See related
    Ensembl:ENSMUSG00000024533
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sp; Spir-1; AI415299; AU022898; AW550622; 6030430B19Rik
    Expression
    Broad expression in cerebellum adult (RPKM 16.5), frontal lobe adult (RPKM 16.3) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Spire1 in Genome Data Viewer
    Location:
    18; 18 E1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (67621279..67745880, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (67488209..67612810, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (67647863..67712375, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene AFG3-like AAA ATPase 2 Neighboring gene PRELI domain containing 3A Neighboring gene predicted gene, 17669 Neighboring gene centrosomal protein 76 Neighboring gene proteasome (prosome, macropain) assembly chaperone 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in Golgi vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within Golgi vesicle transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament network formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cleavage furrow formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cleavage furrow formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dendritic spine development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of meiotic spindle localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in establishment of meiotic spindle localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of meiotic spindle localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in formin-nucleated actin cable assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in formin-nucleated actin cable assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in intracellular transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in polar body extrusion after meiotic divisions IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in polar body extrusion after meiotic divisions IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial fission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cleavage furrow IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasmic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein spire homolog 1
    Names
    spire homolog 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176832.2NP_789802.1  protein spire homolog 1 isoform 2

      See identical proteins and their annotated locations for NP_789802.1

      Status: VALIDATED

      Source sequence(s)
      AC120410
      Consensus CDS
      CCDS37849.1
      UniProtKB/TrEMBL
      A0A286YDN9
      Related
      ENSMUSP00000153492.2, ENSMUST00000224799.2
      Conserved Domains (1) summary
      cd15767
      Location:347467
      FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
    2. NM_194355.3NP_919336.2  protein spire homolog 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC120410
      Conserved Domains (2) summary
      cd15767
      Location:620740
      FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
      pfam16474
      Location:24223
      KIND; Kinase non-catalytic C-lobe domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      67621279..67745880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526206.2XP_006526269.1  protein spire homolog 1 isoform X4

      Related
      ENSMUSP00000110702.4, ENSMUST00000115050.10
      Conserved Domains (2) summary
      cd15767
      Location:575695
      FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
      pfam16474
      Location:24223
      KIND; Kinase non-catalytic C-lobe domain
    2. XM_006526203.5XP_006526266.1  protein spire homolog 1 isoform X2

      Conserved Domains (2) summary
      cd15767
      Location:633753
      FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
      pfam16474
      Location:24223
      KIND; Kinase non-catalytic C-lobe domain
    3. XM_006526205.2XP_006526268.1  protein spire homolog 1 isoform X3

      Conserved Domains (2) summary
      cd15767
      Location:576696
      FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
      pfam16474
      Location:24223
      KIND; Kinase non-catalytic C-lobe domain
    4. XM_006526209.5XP_006526272.1  protein spire homolog 1 isoform X1

      Conserved Domains (2) summary
      cd15767
      Location:634754
      FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
      pfam16474
      Location:24223
      KIND; Kinase non-catalytic C-lobe domain
    5. XM_006526207.5XP_006526270.1  protein spire homolog 1 isoform X5

      Conserved Domains (2) summary
      cd15767
      Location:562682
      FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
      pfam16474
      Location:24223
      KIND; Kinase non-catalytic C-lobe domain
    6. XM_036161268.1XP_036017161.1  protein spire homolog 1 isoform X8

      Related
      ENSMUSP00000080871.7, ENSMUST00000082243.7
      Conserved Domains (6) summary
      cd15767
      Location:417537
      FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
      cd22065
      Location:102133
      WH2_Spire_1-2_r1; first tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homologs 1 and 2
      cd22078
      Location:142173
      WH2_Spire1_r2-like; second tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homolog 1 (Spir1), and related proteins
      cd22080
      Location:207230
      WH2_Spire1_r4; fourth tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homolog 1
      cd22186
      Location:176198
      WH2_Spire1-2_r3; third tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homologs 1 and 2
      cl21453
      Location:178
      PKc_like; Protein Kinases, catalytic domain
    7. XM_030250590.2XP_030106450.1  protein spire homolog 1 isoform X7

      Related
      ENSMUSP00000049336.7, ENSMUST00000045105.13
      Conserved Domains (2) summary
      cd15767
      Location:475595
      FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
      cl21453
      Location:178
      PKc_like; Protein Kinases, catalytic domain
    8. XM_030250587.2XP_030106447.1  protein spire homolog 1 isoform X6

      Conserved Domains (2) summary
      cd15767
      Location:489609
      FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
      cl21453
      Location:178
      PKc_like; Protein Kinases, catalytic domain
    9. XM_030250586.2XP_030106446.1  protein spire homolog 1 isoform X6

      Conserved Domains (2) summary
      cd15767
      Location:489609
      FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
      cl21453
      Location:178
      PKc_like; Protein Kinases, catalytic domain
    10. XM_030250589.2XP_030106449.1  protein spire homolog 1 isoform X7

      Conserved Domains (2) summary
      cd15767
      Location:475595
      FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
      cl21453
      Location:178
      PKc_like; Protein Kinases, catalytic domain
    11. XM_030250591.2XP_030106451.1  protein spire homolog 1 isoform X8

      Conserved Domains (6) summary
      cd15767
      Location:417537
      FYVE_SPIR1; FYVE-related domain found in protein spire homolog 1 (Spire1) and similar proteins
      cd22065
      Location:102133
      WH2_Spire_1-2_r1; first tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homologs 1 and 2
      cd22078
      Location:142173
      WH2_Spire1_r2-like; second tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homolog 1 (Spir1), and related proteins
      cd22080
      Location:207230
      WH2_Spire1_r4; fourth tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homolog 1
      cd22186
      Location:176198
      WH2_Spire1-2_r3; third tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homologs 1 and 2
      cl21453
      Location:178
      PKc_like; Protein Kinases, catalytic domain
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