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    Pwwp3a PWWP domain containing 3A, DNA repair factor [ Mus musculus (house mouse) ]

    Gene ID: 68114, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pwwp3aprovided by MGI
    Official Full Name
    PWWP domain containing 3A, DNA repair factorprovided by MGI
    Primary source
    MGI:MGI:1915364
    See related
    Ensembl:ENSMUSG00000020156
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mum1; UBE-1C2; 2610019J09; 9430059D04Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 52.6), CNS E11.5 (RPKM 26.1) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Pwwp3a in Genome Data Viewer
    Location:
    10; 10 C1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80062265..80080978)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80226431..80245144)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (79689343..79707889)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 174, member C Neighboring gene ephrin A2 Neighboring gene nuclear encoded tRNA pheylalanine 3 (anticodon GAA) Neighboring gene nuclear encoded tRNA asparagine 7 (anticodon GTT) Neighboring gene NADH:ubiquinone oxidoreductase core subunit S7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nucleosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in chromatin organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    PWWP domain-containing DNA repair factor 3A
    Names
    MUM-1
    PWWP domain-containing protein MUM1
    melanoma associated antigen (mutated) 1
    mutated melanoma-associated antigen 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023431.5NP_075920.4  PWWP domain-containing DNA repair factor 3A

      See identical proteins and their annotated locations for NP_075920.4

      Status: PROVISIONAL

      Source sequence(s)
      AK158750
      Consensus CDS
      CCDS24014.1
      UniProtKB/Swiss-Prot
      Q6DID5
      Related
      ENSMUSP00000020365.9, ENSMUST00000020365.15
      Conserved Domains (1) summary
      cd06080
      Location:381460
      MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80062265..80080978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245246.1XP_030101106.1  PWWP domain-containing DNA repair factor 3A isoform X1

      Conserved Domains (1) summary
      cd06080
      Location:381460
      MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...
    2. XM_006514026.2XP_006514089.1  PWWP domain-containing DNA repair factor 3A isoform X2

      Conserved Domains (1) summary
      cd06080
      Location:381460
      MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...
    3. XM_006514025.3XP_006514088.1  PWWP domain-containing DNA repair factor 3A isoform X1

      See identical proteins and their annotated locations for XP_006514088.1

      UniProtKB/Swiss-Prot
      Q6DID5
      Conserved Domains (1) summary
      cd06080
      Location:381460
      MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...
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