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    Rchy1 ring finger and CHY zinc finger domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 68098, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rchy1provided by MGI
    Official Full Name
    ring finger and CHY zinc finger domain containing 1provided by MGI
    Primary source
    MGI:MGI:1915348
    See related
    Ensembl:ENSMUSG00000029397
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pi; PRO1; ARNIP; CHIMP; Pirh2; Zfp36; Zfp363; Znf363
    Summary
    This gene encodes a protein containing CHY-, CTCHY-, and RING-type zinc-fingers. The encoded protein functions as an E3 ubiquitin ligase, and mediates the degradation of target proteins such as p53. The activity of this protein is important in cell cycle regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
    Expression
    Ubiquitous expression in bladder adult (RPKM 12.9), CNS E14 (RPKM 12.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rchy1 in Genome Data Viewer
    Location:
    5; 5 E2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (92096701..92111004, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (91948842..91963145, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (92377930..92392094, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36303 Neighboring gene predicted gene, 36357 Neighboring gene THAP domain containing 6 Neighboring gene odontogenesis associated phosphoprotein Neighboring gene cyclin-dependent kinase-like 2 (CDC2-related kinase) Neighboring gene predicted gene, 46915

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    RING finger and CHY zinc finger domain-containing protein 1
    Names
    CH-rich-interacting match with PLAG1
    E3 ubiquitin-protein ligase Pirh2
    RING-type E3 ubiquitin transferase RCHY1
    androgen receptor N-terminal-interacting protein
    zinc finger protein 363
    NP_001258726.1
    NP_080833.1
    XP_006535254.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271797.1NP_001258726.1  RING finger and CHY zinc finger domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001258726.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC165433, AK018488, AK078397, DV662964
      Consensus CDS
      CCDS71613.1
      UniProtKB/Swiss-Prot
      Q9CR50
      UniProtKB/TrEMBL
      G3UWD8
      Related
      ENSMUSP00000131270.2, ENSMUST00000169948.2
      Conserved Domains (2) summary
      pfam13639
      Location:104146
      zf-RING_2; Ring finger domain
      pfam14599
      Location:151209
      zinc_ribbon_6; Zinc-ribbon
    2. NM_026557.4NP_080833.1  RING finger and CHY zinc finger domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_080833.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC165433, AK018488, AK078397
      Consensus CDS
      CCDS19424.1
      UniProtKB/Swiss-Prot
      Q9CR50
      Related
      ENSMUSP00000031345.9, ENSMUST00000031345.15
      Conserved Domains (3) summary
      pfam05495
      Location:2093
      zf-CHY; CHY zinc finger
      pfam13639
      Location:144186
      zf-RING_2; Ring finger domain
      pfam14599
      Location:191249
      zinc_ribbon_6; Zinc-ribbon

    RNA

    1. NR_073442.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AK015870, AK018488, AK078397
      Related
      ENSMUST00000140670.8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      92096701..92111004 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535191.4XP_006535254.1  RING finger and CHY zinc finger domain-containing protein 1 isoform X1

      Conserved Domains (2) summary
      cd16464
      Location:58101
      RING-H2_Pirh2; RING finger, H2 subclass, found in p53-induced RING-H2 protein (Pirh2) and similar proteins
      pfam14599
      Location:105163
      zinc_ribbon_6; Zinc-ribbon
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