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    Dynll2 dynein light chain LC8-type 2 [ Mus musculus (house mouse) ]

    Gene ID: 68097, updated on 9-Sep-2018

    Summary

    Official Symbol
    Dynll2provided by MGI
    Official Full Name
    dynein light chain LC8-type 2provided by MGI
    Primary source
    MGI:MGI:1915347
    See related
    Ensembl:ENSMUSG00000020483 Vega:OTTMUSG00000001475
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DLC8; Dlc2; DLC8b; C87222; 1700064A15Rik; 6720463E02Rik
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 107.7), testis adult (RPKM 91.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dynll2 in Genome Data Viewer
    Location:
    11; 11 C
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (87979525..87998298, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (87793027..87811800, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 46263 Neighboring gene ubiquitin-conjugating enzyme MHR6BN pseudogene Neighboring gene predicted gene, 38610 Neighboring gene serine/arginine-rich splicing factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to ATP-dependent microtubule motor activity, plus-end-directed IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ATP-dependent microtubule motor activity, plus-end-directed IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasmic dynein complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cytoplasmic dynein complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule associated complex IEA
    Inferred from Electronic Annotation
    more info
     
    myosin V complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dynein light chain 2, cytoplasmic
    Names
    8 kDa dynein light chain b

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168471.1NP_001161943.1  dynein light chain 2, cytoplasmic

      See identical proteins and their annotated locations for NP_001161943.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK006876, AL604044, AL606805
      Consensus CDS
      CCDS36272.1
      UniProtKB/Swiss-Prot
      Q9D0M5
      Related
      ENSMUSP00000136241.1, ENSMUST00000178105.2
      Conserved Domains (1) summary
      PTZ00059
      Location:189
      PTZ00059; dynein light chain; Provisional
    2. NM_001168472.1NP_001161944.1  dynein light chain 2, cytoplasmic

      See identical proteins and their annotated locations for NP_001161944.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL606805, BY249698
      Consensus CDS
      CCDS36272.1
      UniProtKB/Swiss-Prot
      Q9D0M5
      Related
      ENSMUSP00000103556.3, ENSMUST00000107923.9
      Conserved Domains (1) summary
      PTZ00059
      Location:189
      PTZ00059; dynein light chain; Provisional
    3. NM_026556.4NP_080832.1  dynein light chain 2, cytoplasmic

      See identical proteins and their annotated locations for NP_080832.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK078434, AL606805, BY310878
      Consensus CDS
      CCDS36272.1
      UniProtKB/Swiss-Prot
      Q9D0M5
      Related
      ENSMUSP00000020775.2, OTTMUSP00000001420, ENSMUST00000020775.8, OTTMUST00000002913
      Conserved Domains (1) summary
      PTZ00059
      Location:189
      PTZ00059; dynein light chain; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      87979525..87998298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/ShiLtJ

    Genomic

    1. NT_187003.1 Reference GRCm38.p4 NOD/ShiLtJ

      Range
      1116585..1135338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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