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    Aen apoptosis enhancing nuclease [ Mus musculus (house mouse) ]

    Gene ID: 68048, updated on 31-Jan-2019

    Summary

    Official Symbol
    Aenprovided by MGI
    Official Full Name
    apoptosis enhancing nucleaseprovided by MGI
    Primary source
    MGI:MGI:1915298
    See related
    Ensembl:ENSMUSG00000030609
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Isg20l1; 2700083B06Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 12.3), genital fat pad adult (RPKM 10.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Aen in Genome Data Viewer
    Location:
    7; 7 D2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (78895927..78908833)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (86040813..86053719)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene microRNA 7-2 Neighboring gene predicted gene, 39039 Neighboring gene interferon-stimulated protein Neighboring gene predicted gene, 31213

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    apoptosis-enhancing nuclease
    Names
    interferon stimulated exonuclease gene 20-like 1
    interferon-stimulated 20 kDa exonuclease-like 1
    NP_001156411.1
    NP_080807.3
    XP_006541200.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162939.2NP_001156411.1  apoptosis-enhancing nuclease isoform 2

      See identical proteins and their annotated locations for NP_001156411.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC138376, AK031972, AK165708
      Consensus CDS
      CCDS52277.1
      UniProtKB/Swiss-Prot
      Q9CZI9
      Related
      ENSMUSP00000103044.1, ENSMUST00000107421.7
      Conserved Domains (2) summary
      COG0847
      Location:72229
      DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
      cl10012
      Location:72228
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    2. NM_001360709.1NP_001347638.1  apoptosis-enhancing nuclease isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AC138376, AK031972, CX211663
      Conserved Domains (1) summary
      cl10012
      Location:110266
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    3. NM_026531.5NP_080807.3  apoptosis-enhancing nuclease isoform 1

      See identical proteins and their annotated locations for NP_080807.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AC138376, AK031972
      Consensus CDS
      CCDS39988.2
      UniProtKB/Swiss-Prot
      Q9CZI9
      Related
      ENSMUSP00000103048.1, ENSMUST00000107425.7
      Conserved Domains (1) summary
      cl10012
      Location:110266
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

    RNA

    1. NR_153795.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AC138376

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      78895927..78908833
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541137.2XP_006541200.1  apoptosis-enhancing nuclease isoform X1

      UniProtKB/Swiss-Prot
      Q9CZI9
      Related
      ENSMUSP00000103046.1, ENSMUST00000107423.1
      Conserved Domains (1) summary
      cl10012
      Location:110266
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
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