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    STX1A syntaxin 1A [ Homo sapiens (human) ]

    Gene ID: 6804, updated on 8-Jul-2021

    Summary

    Official Symbol
    STX1Aprovided by HGNC
    Official Full Name
    syntaxin 1Aprovided by HGNC
    Primary source
    HGNC:HGNC:11433
    See related
    Ensembl:ENSG00000106089 MIM:186590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    STX1; HPC-1; P35-1; SYN1A
    Summary
    This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
    Expression
    Biased expression in brain (RPKM 28.2), bone marrow (RPKM 2.7) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See STX1A in Genome Data Viewer
    Location:
    7q11.23
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (73699210..73719673, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (73113540..73133999, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C30 Neighboring gene BUD23 rRNA methyltransferase and ribosome maturation factor Neighboring gene uncharacterized LOC105375350 Neighboring gene microRNA 4284 Neighboring gene Sharpr-MPRA regulatory region 8580 Neighboring gene RNA, 7SL, cytoplasmic 265, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium channel inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chloride channel inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables myosin head/neck binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein N-terminus binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in SNARE complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium-ion regulated exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of calcium ion-dependent exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of catecholamine secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neurotransmitter secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of norepinephrine secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein sumoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of insulin secretion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of synaptic vesicle priming IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to gravity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in secretion by cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic vesicle docking IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SNARE complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in actomyosin IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    syntaxin-1A
    Names
    neuron-specific antigen HPC-1
    syntaxin 1A (brain)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013360.1 RefSeqGene

      Range
      5019..25478
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001165903.2NP_001159375.1  syntaxin-1A isoform 2

      See identical proteins and their annotated locations for NP_001159375.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal segment in the 3' coding region, as compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      BC000444, BC064644, DA159446
      Consensus CDS
      CCDS55120.1
      UniProtKB/Swiss-Prot
      Q16623
      Related
      ENSP00000378585.3, ENST00000395156.7
      Conserved Domains (1) summary
      pfam00804
      Location:30226
      Syntaxin; Syntaxin
    2. NM_004603.4NP_004594.1  syntaxin-1A isoform 1

      See identical proteins and their annotated locations for NP_004594.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC003011, BC064644, DA159446
      Consensus CDS
      CCDS34655.1
      UniProtKB/Swiss-Prot
      Q16623
      UniProtKB/TrEMBL
      Q75ME0
      Related
      ENSP00000222812.3, ENST00000222812.8
      Conserved Domains (2) summary
      pfam00804
      Location:30227
      Syntaxin
      pfam05739
      Location:228279
      SNARE; SNARE domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

      Range
      73699210..73719673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012567.2XP_016868056.1  syntaxin-1A isoform X1

    RNA

    1. XR_242263.2 RNA Sequence

    2. XR_927527.2 RNA Sequence

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