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    Rnf146 ring finger protein 146 [ Mus musculus (house mouse) ]

    Gene ID: 68031, updated on 12-Aug-2018

    Summary

    Official Symbol
    Rnf146provided by MGI
    Official Full Name
    ring finger protein 146provided by MGI
    Primary source
    MGI:MGI:1915281
    See related
    Ensembl:ENSMUSG00000038876 Vega:OTTMUSG00000028056
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Iduna; 2610509H23Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 13.4), CNS E14 (RPKM 12.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Rnf146 in Genome Data Viewer
    Location:
    10; 10 A4
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (29344176..29362442, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (29063982..29082248, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40620 Neighboring gene predicted gene, 46218 Neighboring gene enoyl Coenzyme A hydratase domain containing 1 Neighboring gene predicted gene, 30698 Neighboring gene predicted gene, 40621 Neighboring gene predicted gene, 18903

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    poly-ADP-D-ribose binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of hydrogen peroxide-induced cell death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF146
    Names
    RING-type E3 ubiquitin transferase RNF146
    NP_001103666.1
    NP_001103667.1
    NP_001103668.1
    NP_001271208.1
    NP_080794.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110196.1NP_001103666.1  E3 ubiquitin-protein ligase RNF146

      See identical proteins and their annotated locations for NP_001103666.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal exon in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AK012080, AK035665, BC050795, BF461810, BQ713250
      Consensus CDS
      CCDS48529.1
      UniProtKB/Swiss-Prot
      Q9CZW6
      UniProtKB/TrEMBL
      Q9CTM5
      Related
      ENSMUSP00000124215.1, OTTMUSP00000035294, ENSMUST00000160372.8, OTTMUST00000069490
      Conserved Domains (2) summary
      smart00678
      Location:105177
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd00162
      Location:3779
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    2. NM_001110197.1NP_001103667.1  E3 ubiquitin-protein ligase RNF146

      See identical proteins and their annotated locations for NP_001103667.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All variants encode the same protein.
      Source sequence(s)
      AK035665, BC050795, BF461810, BQ713250, BY787516
      Consensus CDS
      CCDS48529.1
      UniProtKB/Swiss-Prot
      Q9CZW6
      UniProtKB/TrEMBL
      Q9CTM5
      Related
      ENSMUSP00000037224.4, ENSMUST00000037548.10
      Conserved Domains (2) summary
      smart00678
      Location:105177
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd00162
      Location:3779
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    3. NM_001110198.1NP_001103668.1  E3 ubiquitin-protein ligase RNF146

      See identical proteins and their annotated locations for NP_001103668.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AK035665, BC050795, BF461810, BQ713250, BU562186
      Consensus CDS
      CCDS48529.1
      UniProtKB/Swiss-Prot
      Q9CZW6
      UniProtKB/TrEMBL
      Q9CTM5
      Conserved Domains (2) summary
      smart00678
      Location:105177
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd00162
      Location:3779
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    4. NM_001284279.1NP_001271208.1  E3 ubiquitin-protein ligase RNF146

      See identical proteins and their annotated locations for NP_001271208.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has an alternate 5' UTR exon, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AC153912, AK012080, AK016748, BF461810
      Consensus CDS
      CCDS48529.1
      UniProtKB/Swiss-Prot
      Q9CZW6
      Related
      ENSMUSP00000124772.1, OTTMUSP00000035295, ENSMUST00000162335.7, OTTMUST00000069491
      Conserved Domains (2) summary
      smart00678
      Location:105177
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd00162
      Location:3779
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    5. NM_026518.4NP_080794.2  E3 ubiquitin-protein ligase RNF146

      See identical proteins and their annotated locations for NP_080794.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate splice site and also lacks an exon in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AK035665, BC050795, BF461810, BQ713250
      Consensus CDS
      CCDS48529.1
      UniProtKB/Swiss-Prot
      Q9CZW6
      UniProtKB/TrEMBL
      Q9CTM5
      Related
      ENSMUSP00000124288.1, OTTMUSP00000035293, ENSMUST00000160144.8, OTTMUST00000069489
      Conserved Domains (2) summary
      smart00678
      Location:105177
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd00162
      Location:3779
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      29344176..29362442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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