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    Rnf146 ring finger protein 146 [ Mus musculus (house mouse) ]

    Gene ID: 68031, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rnf146provided by MGI
    Official Full Name
    ring finger protein 146provided by MGI
    Primary source
    MGI:MGI:1915281
    See related
    Ensembl:ENSMUSG00000038876
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Id; Iduna; 2610509H23Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 13.4), CNS E14 (RPKM 12.9) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Rnf146 in Genome Data Viewer
    Location:
    10; 10 A4
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (29220172..29238438, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (29344176..29362442, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (29063982..29082248, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene SOGA family member 3 Neighboring gene RIKEN cDNA 9330159F19 gene Neighboring gene predicted gene, 46218 Neighboring gene enoyl Coenzyme A hydratase domain containing 1 Neighboring gene predicted gene, 25596 Neighboring gene predicted gene, 30698 Neighboring gene predicted gene, 40621 Neighboring gene predicted gene, 24286

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables poly-ADP-D-ribose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables poly-ADP-D-ribose binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF146
    Names
    RING-type E3 ubiquitin transferase RNF146
    NP_001103666.1
    NP_001103667.1
    NP_001103668.1
    NP_001271208.1
    NP_080794.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110196.1NP_001103666.1  E3 ubiquitin-protein ligase RNF146

      See identical proteins and their annotated locations for NP_001103666.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal exon in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AK012080, AK035665, BC050795, BF461810, BQ713250
      Consensus CDS
      CCDS48529.1
      UniProtKB/Swiss-Prot
      Q9CZW6
      UniProtKB/TrEMBL
      Q9CTM5
      Related
      ENSMUSP00000124215.2, ENSMUST00000160372.9
      Conserved Domains (2) summary
      smart00678
      Location:105177
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd00162
      Location:3779
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    2. NM_001110197.1NP_001103667.1  E3 ubiquitin-protein ligase RNF146

      See identical proteins and their annotated locations for NP_001103667.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All variants encode the same protein.
      Source sequence(s)
      AK035665, BC050795, BF461810, BQ713250, BY787516
      Consensus CDS
      CCDS48529.1
      UniProtKB/Swiss-Prot
      Q9CZW6
      UniProtKB/TrEMBL
      Q9CTM5
      Related
      ENSMUSP00000037224.5, ENSMUST00000037548.11
      Conserved Domains (2) summary
      smart00678
      Location:105177
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd00162
      Location:3779
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    3. NM_001110198.1NP_001103668.1  E3 ubiquitin-protein ligase RNF146

      See identical proteins and their annotated locations for NP_001103668.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AK035665, BC050795, BF461810, BQ713250, BU562186
      Consensus CDS
      CCDS48529.1
      UniProtKB/Swiss-Prot
      Q9CZW6
      UniProtKB/TrEMBL
      Q9CTM5
      Conserved Domains (2) summary
      smart00678
      Location:105177
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd00162
      Location:3779
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    4. NM_001284279.1NP_001271208.1  E3 ubiquitin-protein ligase RNF146

      See identical proteins and their annotated locations for NP_001271208.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has an alternate 5' UTR exon, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AC153912, AK012080, AK016748, BF461810
      Consensus CDS
      CCDS48529.1
      UniProtKB/Swiss-Prot
      Q9CZW6
      Related
      ENSMUSP00000124772.2, ENSMUST00000162335.8
      Conserved Domains (2) summary
      smart00678
      Location:105177
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd00162
      Location:3779
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    5. NM_026518.4NP_080794.2  E3 ubiquitin-protein ligase RNF146

      See identical proteins and their annotated locations for NP_080794.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate splice site and also lacks an exon in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AK035665, BC050795, BF461810, BQ713250
      Consensus CDS
      CCDS48529.1
      UniProtKB/Swiss-Prot
      Q9CZW6
      UniProtKB/TrEMBL
      Q9CTM5
      Related
      ENSMUSP00000124288.2, ENSMUST00000160144.9
      Conserved Domains (2) summary
      smart00678
      Location:105177
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd00162
      Location:3779
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      29220172..29238438 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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