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    H2bc4 H2B clustered histone 4 [ Mus musculus (house mouse) ]

    Gene ID: 68024, updated on 23-Jun-2021

    Summary

    Official Symbol
    H2bc4provided by MGI
    Official Full Name
    H2B clustered histone 4provided by MGI
    Primary source
    MGI:MGI:1915274
    See related
    Ensembl:ENSMUSG00000018102
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H2bf; H2bc6; H2bc8; H2bfs; R74621; Hist1h2; Hist1h2bc; 2610022J01Rik
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Aug 2015]
    Expression
    Ubiquitous expression in colon adult (RPKM 339.7), small intestine adult (RPKM 307.1) and 28 other tissues See more
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    Genomic context

    See H2bc4 in Genome Data Viewer
    Location:
    13; 13 A3.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (23868182..23876805)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (23684199..23692480)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (23776068..23784349)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22452 Neighboring gene H2A clustered histone 6 Neighboring gene H1.6 linker histone, cluster member Neighboring gene H4 clustered histone 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    histone H2B type 1-C/E/G
    Names
    H2B histone family, member S
    histone 1, H2bc
    histone cluster 1, H2bc

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290380.1NP_001277309.1  histone H2B type 1-C/E/G

      See identical proteins and their annotated locations for NP_001277309.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is intronless and differs from variant 1 in its 3' UTR which contains a palindromic termination sequence. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL592149
      Consensus CDS
      CCDS26357.1
      UniProtKB/Swiss-Prot
      Q6ZWY9
      Conserved Domains (1) summary
      smart00427
      Location:28124
      H2B; Histone H2B
    2. NM_023422.3NP_075911.2  histone H2B type 1-C/E/G

      See identical proteins and their annotated locations for NP_075911.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer, two exon transcript and contains a polyA signal and site. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK011516
      Consensus CDS
      CCDS26357.1
      UniProtKB/Swiss-Prot
      Q6ZWY9
      Related
      ENSMUSP00000018246.5, ENSMUST00000018246.6
      Conserved Domains (1) summary
      smart00427
      Location:28124
      H2B; Histone H2B

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      23868182..23876805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004938062.1 RNA Sequence

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