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    Srsf6 serine and arginine-rich splicing factor 6 [ Mus musculus (house mouse) ]

    Gene ID: 67996, updated on 23-Jun-2021

    Summary

    Official Symbol
    Srsf6provided by MGI
    Official Full Name
    serine and arginine-rich splicing factor 6provided by MGI
    Primary source
    MGI:MGI:1915246
    See related
    Ensembl:ENSMUSG00000016921
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sf; Sfrs6; AI314910; AW146126; 1210001E11Rik
    Summary
    The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Sep 2010]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 167.2), CNS E11.5 (RPKM 118.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Srsf6 in Genome Data Viewer
    Location:
    2 H2; 2 83.87 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (162773428..162779041)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (162931508..162937121)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (162757244..162762857)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene transcriptional adaptor 3 pseudogene Neighboring gene CDGSH iron sulfur domain 3B Neighboring gene L3MBTL1 histone methyl-lysine binding protein Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables pre-mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA splice site selection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mRNA splice site selection ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of type B pancreatic cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in lung morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/arginine-rich splicing factor 6
    Names
    pre-mRNA-splicing factor SRP55
    splicing factor, arginine/serine-rich 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026499.4NP_080775.3  serine/arginine-rich splicing factor 6

      See identical proteins and their annotated locations for NP_080775.3

      Status: REVIEWED

      Source sequence(s)
      AK133872, AL590418, AL606473, BY783855
      Consensus CDS
      CCDS17002.1
      UniProtKB/Swiss-Prot
      Q3TWW8
      Related
      ENSMUSP00000119065.2, ENSMUST00000130411.7
      Conserved Domains (2) summary
      cd12766
      Location:110182
      RRM2_SRSF6; RNA recognition motif 2 (RRM2) found found in vertebrate serine/arginine-rich splicing factor 6 (SRSF6)
      cl17169
      Location:172
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      162773428..162779041
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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