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    Srsf6 serine/arginine-rich splicing factor 6 [ Mus musculus (house mouse) ]

    Gene ID: 67996, updated on 12-Aug-2018

    Summary

    Official Symbol
    Srsf6provided by MGI
    Official Full Name
    serine/arginine-rich splicing factor 6provided by MGI
    Primary source
    MGI:MGI:1915246
    See related
    Ensembl:ENSMUSG00000016921 Vega:OTTMUSG00000001060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sfrs6; AI314910; AW146126; 1210001E11Rik
    Summary
    The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Sep 2010]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 167.2), CNS E11.5 (RPKM 118.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Srsf6 in Genome Data Viewer
    Location:
    2 H2; 2 83.87 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (162931508..162937121)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (162757244..162762857)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39978 Neighboring gene CDGSH iron sulfur domain 3B Neighboring gene L3MBTL1 histone methyl-lysine binding protein Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    pre-mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    pre-mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA cis splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA splice site selection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA splice site selection ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of type B pancreatic cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial cell proliferation involved in lung morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/arginine-rich splicing factor 6
    Names
    pre-mRNA-splicing factor SRP55
    splicing factor, arginine/serine-rich 6

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026499.4NP_080775.3  serine/arginine-rich splicing factor 6

      See identical proteins and their annotated locations for NP_080775.3

      Status: REVIEWED

      Source sequence(s)
      AK133872, AL590418, AL606473, BY783855
      Consensus CDS
      CCDS17002.1
      UniProtKB/Swiss-Prot
      Q3TWW8
      Related
      ENSMUSP00000119065.1, OTTMUSP00000001014, ENSMUST00000130411.6, OTTMUST00000002102
      Conserved Domains (2) summary
      cd12596
      Location:372
      RRM1_SRSF6; RNA recognition motif 1 in vertebrate serine/arginine-rich splicing factor 6 (SRSF6)
      cd12600
      Location:110181
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      162931508..162937121
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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