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    Srsf6 serine and arginine-rich splicing factor 6 [ Mus musculus (house mouse) ]

    Gene ID: 67996, updated on 8-Feb-2024


    Official Symbol
    Srsf6provided by MGI
    Official Full Name
    serine and arginine-rich splicing factor 6provided by MGI
    Primary source
    See related
    Ensembl:ENSMUSG00000016921 AllianceGenome:MGI:1915246
    Gene type
    protein coding
    RefSeq status
    Mus musculus
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sfrs6; 1210001E11Rik
    The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Sep 2010]
    Ubiquitous expression in adrenal adult (RPKM 167.2), CNS E11.5 (RPKM 118.4) and 28 other tissues See more
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    Genomic context

    See Srsf6 in Genome Data Viewer
    2 H2; 2 83.87 cM
    Exon count:
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (162773428..162779041)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (162931508..162937121)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene transcriptional adaptor 3 pseudogene Neighboring gene CDGSH iron sulfur domain 3B Neighboring gene STARR-seq mESC enhancer starr_06291 Neighboring gene STARR-positive B cell enhancer ABC_E7882 Neighboring gene L3MBTL1 histone methyl-lysine binding protein Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products


    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a




    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information


    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    enables pre-mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info

    General protein information

    Preferred Names
    serine/arginine-rich splicing factor 6
    pre-mRNA-splicing factor SRP55
    splicing factor, arginine/serine-rich 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026499.4NP_080775.3  serine/arginine-rich splicing factor 6

      See identical proteins and their annotated locations for NP_080775.3

      Status: REVIEWED

      Source sequence(s)
      AK133872, AL590418, AL606473, BY783855
      Consensus CDS
      Q3TWW8, Q3UJV5, Q921K3, Q9DBP1
      ENSMUSP00000119065.2, ENSMUST00000130411.7
      Conserved Domains (2) summary
      RRM2_SRSF6; RNA recognition motif 2 (RRM2) found found in vertebrate serine/arginine-rich splicing factor 6 (SRSF6)
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J


    1. NC_000068.8 Reference GRCm39 C57BL/6J

      GenBank, FASTA, Sequence Viewer (Graphics)