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    Gnpda2 glucosamine-6-phosphate deaminase 2 [ Mus musculus (house mouse) ]

    Gene ID: 67980, updated on 23-Jun-2021

    Summary

    Official Symbol
    Gnpda2provided by MGI
    Official Full Name
    glucosamine-6-phosphate deaminase 2provided by MGI
    Primary source
    MGI:MGI:1915230
    See related
    Ensembl:ENSMUSG00000029209
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gn; Gnp2; Sb52; GNPDA; BB189630; mKIAA4008; 4921523I18Rik; 4933412A11Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 5.6), testis adult (RPKM 4.1) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Gnpda2 in Genome Data Viewer
    Location:
    5; 5 C3.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (69732344..69749684, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (69574998..69592332, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (69966240..69983524, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Yip1 domain family, member 7 Neighboring gene GUF1 homolog, GTPase Neighboring gene predicted gene, 26044 Neighboring gene predicted gene, 23661

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4008

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glucosamine-6-phosphate deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables glucosamine-6-phosphate deaminase activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in N-acetylglucosamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in N-acetylglucosamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in N-acetylneuraminate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in UDP-N-acetylglucosamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glucosamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    glucosamine-6-phosphate isomerase 2
    Names
    GNPDA 2
    glcN6P deaminase 2
    oscillin
    NP_001033104.1
    NP_001334292.1
    NP_001346168.1
    XP_011239068.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038015.2NP_001033104.1  glucosamine-6-phosphate isomerase 2 isoform 1

      See identical proteins and their annotated locations for NP_001033104.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC109186
      Consensus CDS
      CCDS19324.1
      UniProtKB/Swiss-Prot
      Q9CRC9
      Related
      ENSMUSP00000031117.7, ENSMUST00000031117.13
      Conserved Domains (1) summary
      PRK00443
      Location:1258
      nagB; glucosamine-6-phosphate deaminase; Provisional
    2. NM_001347363.1NP_001334292.1  glucosamine-6-phosphate isomerase 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC109186
      Consensus CDS
      CCDS84888.1
      UniProtKB/Swiss-Prot
      Q9CRC9
      Related
      ENSMUSP00000133490.2, ENSMUST00000173927.8
      Conserved Domains (1) summary
      cl00339
      Location:1251
      SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...
    3. NM_001359239.1NP_001346168.1  glucosamine-6-phosphate isomerase 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC109186, AK051596
      Consensus CDS
      CCDS89926.1
      Related
      ENSMUSP00000112484.2, ENSMUST00000120789.8
      Conserved Domains (1) summary
      cl00339
      Location:1253
      SugarP_isomerase; Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      69732344..69749684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240766.2XP_011239068.1  glucosamine-6-phosphate isomerase 2 isoform X1

      Conserved Domains (1) summary
      cl00339
      Location:1139
      SugarP_isomerase; Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_027681.1: Suppressed sequence

      Description
      NM_027681.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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