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    Ccny cyclin Y [ Mus musculus (house mouse) ]

    Gene ID: 67974, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ccnyprovided by MGI
    Official Full Name
    cyclin Yprovided by MGI
    Primary source
    MGI:MGI:1915224
    See related
    Ensembl:ENSMUSG00000024286 AllianceGenome:MGI:1915224
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700025H17Rik; 3110050L10Rik; 4631402G10Rik; 5730405I09Rik
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in several processes, including G2/M transition of mitotic cell cycle; positive regulation of cyclin-dependent protein serine/threonine kinase activity; and regulation of canonical Wnt signaling pathway. Part of cyclin-dependent protein kinase holoenzyme complex. Is expressed in several structures, including cerebral cortex; genitourinary system; gut; mammary gland; and spleen. Orthologous to human CCNY (cyclin Y). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 25.9), ovary adult (RPKM 20.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ccny in Genome Data Viewer
    Location:
    18 A1; 18 4.91 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (9312304..9450188, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (9312304..9450154, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1632 Neighboring gene frizzled class receptor 8 Neighboring gene STARR-seq mESC enhancer starr_43772 Neighboring gene STARR-seq mESC enhancer starr_43773 Neighboring gene STARR-seq mESC enhancer starr_43774 Neighboring gene gap junction protein, delta 4 Neighboring gene STARR-positive B cell enhancer ABC_E7573 Neighboring gene STARR-seq mESC enhancer starr_43776 Neighboring gene predicted gene, 35458 Neighboring gene family with sequence similarity 76, member A pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cyclin-dependent protein serine/threonine kinase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G2/M transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    cyclin-Y
    Names
    cyclin fold protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026484.4NP_080760.2  cyclin-Y

      See identical proteins and their annotated locations for NP_080760.2

      Status: VALIDATED

      Source sequence(s)
      AC108777, AK014201, AK014507, AK028696, AW048376
      Consensus CDS
      CCDS29050.1
      UniProtKB/Swiss-Prot
      Q8BGU5, Q8CI87, Q9CYN5
      Related
      ENSMUSP00000050001.5, ENSMUST00000053917.6
      Conserved Domains (1) summary
      cd20540
      Location:166262
      CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      9312304..9450188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250583.2XP_030106443.1  cyclin-Y isoform X2

      Conserved Domains (1) summary
      pfam00134
      Location:101223
      Cyclin_N; Cyclin, N-terminal domain
    2. XM_030250584.2XP_030106444.1  cyclin-Y isoform X4

      Conserved Domains (1) summary
      cd20540
      Location:27123
      CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family
    3. XM_036161266.1XP_036017159.1  cyclin-Y isoform X4

      Conserved Domains (1) summary
      cd20540
      Location:27123
      CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family
    4. XM_030250582.1XP_030106442.1  cyclin-Y isoform X1

      Conserved Domains (1) summary
      pfam00134
      Location:89211
      Cyclin_N; Cyclin, N-terminal domain
    5. XM_036161265.1XP_036017158.1  cyclin-Y isoform X3

      Conserved Domains (1) summary
      cl40454
      Location:166193
      CYCLIN_SF; Cyclin box fold superfamily