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    Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 [ Mus musculus (house mouse) ]

    Gene ID: 67972, updated on 22-Aug-2021

    Summary

    Official Symbol
    Atp2b1provided by MGI
    Official Full Name
    ATPase, Ca++ transporting, plasma membrane 1provided by MGI
    Primary source
    MGI:MGI:104653
    See related
    Ensembl:ENSMUSG00000019943
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PMC; Pmca1; 2810442I22Rik; E130111D10Rik
    Expression
    Broad expression in frontal lobe adult (RPKM 30.2), cortex adult (RPKM 27.6) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Atp2b1 in Genome Data Viewer
    Location:
    10; 10 C3
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (98750243..98862005)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (98914630..99026143)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (98377786..98488777)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40750 Neighboring gene predicted gene, 34346 Neighboring gene predicted gene, 53607 Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 pseudogene Neighboring gene polypeptide N-acetylgalactosaminyltransferase 4 Neighboring gene POC1 centriolar protein B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase-coupled cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables P-type calcium transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    enables PDZ domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion export ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within calcium ion transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of vascular associated smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in immunological synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in integral component of presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    plasma membrane calcium-transporting ATPase 1
    Names
    plasma membrane calcium ATPase
    plasma membrane calcium pump
    NP_001346435.1
    NP_001346436.1
    NP_001346437.1
    NP_001346438.1
    NP_080758.1
    XP_011241850.1
    XP_011241851.1
    XP_030101104.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359506.1NP_001346435.1  plasma membrane calcium-transporting ATPase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC153906, AC160410, AI892140, AK133920, BI732378, BQ176881, CF750345, CJ128577, CJ321142, CK393435, CK624413, CN691756, CV559947
      Conserved Domains (2) summary
      TIGR01517
      Location:151064
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:11031178
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    2. NM_001359507.1NP_001346436.1  plasma membrane calcium-transporting ATPase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153906, AC160410, AI892140, AK133920, BI732378, BQ176881, CF750345, CJ321142, CK393435, CK624413, CN691756, CV559947
      Conserved Domains (2) summary
      TIGR01517
      Location:151064
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:11031142
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    3. NM_001359508.1NP_001346437.1  plasma membrane calcium-transporting ATPase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153906, AC160410, AI892140, AK133920, BI732378, BQ176881, CF750345, CJ128577, CJ321142, CK393435, CK624413, CN691756, CV559947
      Conserved Domains (2) summary
      TIGR01517
      Location:151064
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:11031142
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    4. NM_001359509.1NP_001346438.1  plasma membrane calcium-transporting ATPase 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153906, AC160410, AI892140, AK133920, BI732378, BQ176881, CF750345, CJ128577, CJ321142, CK393435, CK624413, CN691756, CV559947
      Conserved Domains (2) summary
      TIGR01517
      Location:151064
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:11031142
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    5. NM_026482.2NP_080758.1  plasma membrane calcium-transporting ATPase 1 isoform 2

      See identical proteins and their annotated locations for NP_080758.1

      Status: VALIDATED

      Source sequence(s)
      AC153906, AC160410, AI892140, AK133920, BC030901, CJ321142
      Consensus CDS
      CCDS24145.1
      UniProtKB/Swiss-Prot
      G5E829
      Related
      ENSMUSP00000020107.8, ENSMUST00000020107.8
      Conserved Domains (2) summary
      TIGR01517
      Location:151064
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:11031149
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      98750243..98862005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243549.4XP_011241851.1  plasma membrane calcium-transporting ATPase 1 isoform X2

      See identical proteins and their annotated locations for XP_011241851.1

      UniProtKB/Swiss-Prot
      G5E829
      Conserved Domains (2) summary
      TIGR01517
      Location:151064
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:11031149
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    2. XM_011243548.4XP_011241850.1  plasma membrane calcium-transporting ATPase 1 isoform X1

      See identical proteins and their annotated locations for XP_011241850.1

      Conserved Domains (2) summary
      TIGR01517
      Location:151064
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:11031178
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    3. XM_030245244.1XP_030101104.1  plasma membrane calcium-transporting ATPase 1 isoform X1

      Conserved Domains (2) summary
      TIGR01517
      Location:151064
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:11031178
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
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