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    Pold3 polymerase (DNA-directed), delta 3, accessory subunit [ Mus musculus (house mouse) ]

    Gene ID: 67967, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pold3provided by MGI
    Official Full Name
    polymerase (DNA-directed), delta 3, accessory subunitprovided by MGI
    Primary source
    MGI:MGI:1915217
    See related
    Ensembl:ENSMUSG00000030726
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P6; P66; P68; C85233; 2410142G14Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 18.4), liver E14 (RPKM 17.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Pold3 in Genome Data Viewer
    Location:
    7; 7 E2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (99731317..99770709, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100082110..100121502, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (107230623..107270010, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene SET translocation pseudogene Neighboring gene chordin-like 2 Neighboring gene predicted gene, 34760 Neighboring gene predicted gene, 51452 Neighboring gene lipoyl(octanoyl) transferase 2 (putative)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA strand elongation involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in DNA synthesis involved in UV-damage excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in DNA-dependent DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleotide-excision repair, DNA gap filling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nucleotide-excision repair, DNA gap filling ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of delta DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of delta DNA polymerase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of delta DNA polymerase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of zeta DNA polymerase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA polymerase delta subunit 3
    Names
    DNA polymerase delta subunit p66
    GC12
    polymerase (DNA directed), delta 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368380.1NP_001355309.1  DNA polymerase delta subunit 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC161205
    2. NM_133692.2NP_598453.1  DNA polymerase delta subunit 3 isoform 1

      See identical proteins and their annotated locations for NP_598453.1

      Status: VALIDATED

      Source sequence(s)
      AK031778
      Consensus CDS
      CCDS21493.1
      UniProtKB/TrEMBL
      Q8BH76
      Related
      ENSMUSP00000032969.8, ENSMUST00000032969.14
      Conserved Domains (2) summary
      pfam09507
      Location:19461
      CDC27; DNA polymerase subunit Cdc27
      cl04813
      Location:243340
      EIN3; Ethylene insensitive 3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      99731317..99770709 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242944.2XP_030098804.1  DNA polymerase delta subunit 3 isoform X3

      Conserved Domains (1) summary
      pfam09507
      Location:6272
      CDC27; DNA polymerase subunit Cdc27
    2. XM_006508150.5XP_006508213.1  DNA polymerase delta subunit 3 isoform X1

      Conserved Domains (1) summary
      pfam09507
      Location:1423
      CDC27; DNA polymerase subunit Cdc27
    3. XM_030242943.2XP_030098803.1  DNA polymerase delta subunit 3 isoform X2

      Related
      ENSMUSP00000146603.2, ENSMUST00000208670.2
      Conserved Domains (1) summary
      pfam09507
      Location:1422
      CDC27; DNA polymerase subunit Cdc27
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