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    Puf60 poly-U binding splicing factor 60 [ Mus musculus (house mouse) ]

    Gene ID: 67959, updated on 23-Jun-2021

    Summary

    Official Symbol
    Puf60provided by MGI
    Official Full Name
    poly-U binding splicing factor 60provided by MGI
    Primary source
    MGI:MGI:1915209
    See related
    Ensembl:ENSMUSG00000002524
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SIAHBP1; 2410104I19Rik; 2810454F19Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 127.4), adrenal adult (RPKM 124.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Puf60 in Genome Data Viewer
    Location:
    15; 15 D3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75942031..75954386, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76070182..76082537, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (75900612..75911376, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 83, member H Neighboring gene IQ motif and ankyrin repeat containing 1 Neighboring gene scribbled planar cell polarity Neighboring gene microRNA 6952 Neighboring gene predicted gene, 48952 Neighboring gene nuclear receptor binding protein 2 Neighboring gene predicted gene, 41349

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA splice site selection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    poly(U)-binding-splicing factor PUF60
    Names
    60 kDa poly(U)-binding-splicing factor
    fuse-binding protein-interacting repressor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164600.1NP_001158072.1  poly(U)-binding-splicing factor PUF60 isoform c

      See identical proteins and their annotated locations for NP_001158072.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AC116487, AK168789, AW488875
      UniProtKB/Swiss-Prot
      Q3UEB3
      Conserved Domains (1) summary
      TIGR01645
      Location:1499
      half-pint; poly-U binding splicing factor, half-pint family
    2. NM_001356629.1NP_001343558.1  poly(U)-binding-splicing factor PUF60 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC116487
      Conserved Domains (1) summary
      TIGR01645
      Location:2557
      half-pint; poly-U binding splicing factor, half-pint family
    3. NM_001378984.1NP_001365913.1  poly(U)-binding-splicing factor PUF60 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC116487
      Conserved Domains (1) summary
      TIGR01645
      Location:9563
      half-pint; poly-U binding splicing factor, half-pint family
    4. NM_001378985.1NP_001365914.1  poly(U)-binding-splicing factor PUF60 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC116487
      Conserved Domains (1) summary
      TIGR01645
      Location:9546
      half-pint; poly-U binding splicing factor, half-pint family
    5. NM_001378986.1NP_001365915.1  poly(U)-binding-splicing factor PUF60 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC116487
      Conserved Domains (1) summary
      TIGR01645
      Location:2540
      half-pint; poly-U binding splicing factor, half-pint family
    6. NM_028364.2NP_082640.2  poly(U)-binding-splicing factor PUF60 isoform a

      See identical proteins and their annotated locations for NP_082640.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK146534, AK151526, AW488875, BY296547
      Consensus CDS
      CCDS37112.1
      UniProtKB/Swiss-Prot
      Q3UEB3
      Related
      ENSMUSP00000098096.5, ENSMUST00000100527.13
      Conserved Domains (1) summary
      TIGR01645
      Location:7564
      half-pint; poly-U binding splicing factor, half-pint family
    7. NM_133691.5NP_598452.2  poly(U)-binding-splicing factor PUF60 isoform b

      See identical proteins and their annotated locations for NP_598452.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AK151526, AW488875, BY296547
      Consensus CDS
      CCDS37111.1
      UniProtKB/Swiss-Prot
      Q3UEB3
      Related
      ENSMUSP00000002599.10, ENSMUST00000002599.11
      Conserved Domains (1) summary
      TIGR01645
      Location:7547
      half-pint; poly-U binding splicing factor, half-pint family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      75942031..75954386 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248718.1XP_030104578.1  poly(U)-binding-splicing factor PUF60 isoform X1

      Conserved Domains (1) summary
      TIGR01645
      Location:41598
      half-pint; poly-U binding splicing factor, half-pint family
    2. XM_036159555.1XP_036015448.1  poly(U)-binding-splicing factor PUF60 isoform X2

      Conserved Domains (1) summary
      TIGR01645
      Location:1516
      half-pint; poly-U binding splicing factor, half-pint family
    3. XM_036159556.1XP_036015449.1  poly(U)-binding-splicing factor PUF60 isoform X3

      Conserved Domains (1) summary
      TIGR01645
      Location:1499
      half-pint; poly-U binding splicing factor, half-pint family
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