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    Myl12b myosin, light chain 12B, regulatory [ Mus musculus (house mouse) ]

    Gene ID: 67938, updated on 8-Oct-2018

    Summary

    Official Symbol
    Myl12bprovided by MGI
    Official Full Name
    myosin, light chain 12B, regulatoryprovided by MGI
    Primary source
    MGI:MGI:107494
    See related
    Ensembl:ENSMUSG00000034868 Vega:OTTMUSG00000016301
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RLC-B; C77744; Mylc2b; 1500001M02Rik
    Expression
    Ubiquitous expression in large intestine adult (RPKM 289.2), lung adult (RPKM 224.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Myl12b in Genome Data Viewer
    Location:
    17; 17 E1.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (70973963..70990516, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (71323303..71339856, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L12 pseudogene Neighboring gene predicted gene, 46595 Neighboring gene predicted gene, 41611 Neighboring gene myosin, light chain 12A, regulatory, non-sarcomeric Neighboring gene predicted gene, 46596

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    myosin heavy chain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myosin II complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myosin complex IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    myosin regulatory light chain 12B
    Names
    MLC20
    myosin light chain, regulatory B
    myosin regulatory light chain 2-B, smooth muscle isoform
    myosin regulatory light chain 20 kDa
    myosin regulatory light chain MRLC2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023402.2NP_075891.1  myosin regulatory light chain 12B

      See identical proteins and their annotated locations for NP_075891.1

      Status: PROVISIONAL

      Source sequence(s)
      AK002885
      Consensus CDS
      CCDS28954.1
      UniProtKB/Swiss-Prot
      Q3THE2
      Related
      ENSMUSP00000042364.8, OTTMUSP00000017496, ENSMUST00000038446.9, OTTMUST00000039170
      Conserved Domains (1) summary
      COG5126
      Location:19169
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      70973963..70990516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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