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    STK10 serine/threonine kinase 10 [ Homo sapiens (human) ]

    Gene ID: 6793, updated on 5-Mar-2024

    Summary

    Official Symbol
    STK10provided by HGNC
    Official Full Name
    serine/threonine kinase 10provided by HGNC
    Primary source
    HGNC:HGNC:11388
    See related
    Ensembl:ENSG00000072786 MIM:603919; AllianceGenome:HGNC:11388
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LOK; PRO2729
    Summary
    This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in spleen (RPKM 23.3), bone marrow (RPKM 21.8) and 23 other tissues See more
    Orthologs
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    Genomic context

    See STK10 in Genome Data Viewer
    Location:
    5q35.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (172042079..172188224, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (172582378..172728531, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (171469083..171615228, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986476 Neighboring gene F-box and WD repeat domain containing 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:171350031-171350531 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:171349530-171350030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:171370553-171371052 Neighboring gene Sharpr-MPRA regulatory region 1765 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:171407408-171407976 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:171410187-171410959 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16613 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23618 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:171433526-171434153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16614 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:171435409-171436036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:171481332-171482159 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:171482181-171482682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:171482683-171483182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23620 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:171528850-171529636 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23621 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:171542101-171542601 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:171571210-171571710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23623 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23624 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:171578576-171578751 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:171591501-171592480 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:171602275-171602501 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23625 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:171606399-171607102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23629 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16617 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16618 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:171615213-171615988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23630 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23631 Neighboring gene EF-hand calcium binding domain 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23632 Neighboring gene small nucleolar RNA SNORA57 Neighboring gene ubiquitin domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lymphocyte aggregation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
     
    involved_in regulation of lymphocyte migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of lymphocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase 10
    Names
    lymphocyte-oriented kinase
    NP_005981.3
    XP_047273583.1
    XP_047273584.1
    XP_047273585.1
    XP_054209287.1
    XP_054209288.1
    XP_054209289.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005990.4NP_005981.3  serine/threonine-protein kinase 10

      See identical proteins and their annotated locations for NP_005981.3

      Status: REVIEWED

      Source sequence(s)
      AB015718, AC113342, AI584023, BI459912, DA507768, DB068209
      Consensus CDS
      CCDS34290.1
      UniProtKB/Swiss-Prot
      A6ND35, B2R8F5, B3KMY1, O94804, Q6NSK0, Q9UIW4
      Related
      ENSP00000176763.5, ENST00000176763.10
      Conserved Domains (3) summary
      cd06644
      Location:23314
      STKc_STK10; Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase or LOK)
      smart00220
      Location:36294
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12474
      Location:755895
      PKK; Polo kinase kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      172042079..172188224 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417629.1XP_047273585.1  serine/threonine-protein kinase 10 isoform X3

    2. XM_047417628.1XP_047273584.1  serine/threonine-protein kinase 10 isoform X2

    3. XM_047417627.1XP_047273583.1  serine/threonine-protein kinase 10 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      172582378..172728531 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353314.1XP_054209289.1  serine/threonine-protein kinase 10 isoform X3

    2. XM_054353313.1XP_054209288.1  serine/threonine-protein kinase 10 isoform X2

    3. XM_054353312.1XP_054209287.1  serine/threonine-protein kinase 10 isoform X1