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    Plpp3 phospholipid phosphatase 3 [ Mus musculus (house mouse) ]

    Gene ID: 67916, updated on 16-Oct-2021

    Summary

    Official Symbol
    Plpp3provided by MGI
    Official Full Name
    phospholipid phosphatase 3provided by MGI
    Primary source
    MGI:MGI:1915166
    See related
    Ensembl:ENSMUSG00000028517
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lpp3; PRG-2; Ppab2b; Ppap2b; AV025606; D4Bwg0538e; D4Bwg1535e; 1110003O22Rik; 2610002D05Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 134.7), lung adult (RPKM 77.9) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Plpp3 in Genome Data Viewer
    Location:
    4 C6; 4 49.18 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (105014544..105089964)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (105157347..105232767)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (104829952..104905372)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36893 Neighboring gene predicted gene, 29838 Neighboring gene predicted gene, 54244 Neighboring gene predicted gene, 40217

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ceramide-1-phosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables integrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables lipid phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sphingosine-1-phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables sphingosine-1-phosphate phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables sphingosine-1-phosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Bergmann glial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in canonical Wnt signaling pathway involved in positive regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell-cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ceramide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within gastrulation with mouth forming second IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in homotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phospholipid dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within phospholipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phospholipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein stabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of sphingolipid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in sphingosine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phospholipid phosphatase 3
    Names
    PAP-2b
    PAP2-beta
    PAP2b
    lipid phosphate phosphohydrolase 3
    phosphatidate phosphohydrolase type 2b
    phosphatidic acid phosphatase 2b
    phosphatidic acid phosphatase type 2B
    NP_542122.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080555.2NP_542122.1  phospholipid phosphatase 3

      See identical proteins and their annotated locations for NP_542122.1

      Status: VALIDATED

      Source sequence(s)
      AK159136, AK160056, AV018880, BY129827
      Consensus CDS
      CCDS18417.1
      UniProtKB/Swiss-Prot
      Q99JY8
      Related
      ENSMUSP00000065719.8, ENSMUST00000064139.8
      Conserved Domains (1) summary
      cd03384
      Location:126272
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      105014544..105089964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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