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    Rnmt RNA (guanine-7-) methyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 67897, updated on 2-Aug-2021

    Summary

    Official Symbol
    Rnmtprovided by MGI
    Official Full Name
    RNA (guanine-7-) methyltransferaseprovided by MGI
    Primary source
    MGI:MGI:1915147
    See related
    Ensembl:ENSMUSG00000009535
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rg7mt1; AI848273; mKIAA0398; 2610002P10Rik
    Expression
    Broad expression in CNS E18 (RPKM 9.2), CNS E14 (RPKM 8.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rnmt in Genome Data Viewer
    Location:
    18; 18 E2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (68433406..68457923)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (68300233..68324852)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (68460009..68484506)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 4 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene family with sequence similarity 210, member A Neighboring gene microRNA 7219 Neighboring gene predicted gene, 54023 Neighboring gene melanocortin 5 receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA (guanine-N7-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mRNA (guanine-N7-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in 7-methylguanosine mRNA capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within 7-methylguanosine mRNA capping ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in 7-methylguanosine mRNA capping ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    part_of mRNA cap binding complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of mRNA cap binding complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of mRNA cap methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    mRNA cap guanine-N7 methyltransferase
    Names
    mRNA (guanine-N(7)-)-methyltransferase
    mRNA cap methyltransferase
    NP_001164424.1
    NP_001347931.1
    NP_001347932.1
    NP_080716.1
    XP_006526256.1
    XP_006526260.1
    XP_011245293.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170953.1NP_001164424.1  mRNA cap guanine-N7 methyltransferase isoform 2

      See identical proteins and their annotated locations for NP_001164424.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame exon in the 3' coding region, compared to variant 3. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC111069, AK129130, CO039099
      Consensus CDS
      CCDS50314.1
      UniProtKB/Swiss-Prot
      Q9D0L8
      Related
      ENSMUSP00000025427.8, ENSMUST00000025427.14
      Conserved Domains (2) summary
      COG0500
      Location:160335
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      cl17173
      Location:125409
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. NM_001361002.1NP_001347931.1  mRNA cap guanine-N7 methyltransferase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 3 and 4 encode the same protein.
      Source sequence(s)
      AC111069
      Consensus CDS
      CCDS37852.1
      Conserved Domains (1) summary
      pfam03291
      Location:125464
      Pox_MCEL; mRNA capping enzyme
    3. NM_001361003.1NP_001347932.1  mRNA cap guanine-N7 methyltransferase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1, 3 and 4 encode the same protein.
      Source sequence(s)
      AC111069
      Consensus CDS
      CCDS37852.1
      Conserved Domains (1) summary
      pfam03291
      Location:125464
      Pox_MCEL; mRNA capping enzyme
    4. NM_026440.4NP_080716.1  mRNA cap guanine-N7 methyltransferase isoform 1

      See identical proteins and their annotated locations for NP_080716.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1, 3 and 4 encode the same protein.
      Source sequence(s)
      AC111069, AK129130, CO039099
      Consensus CDS
      CCDS37852.1
      UniProtKB/Swiss-Prot
      Q9D0L8
      Related
      ENSMUSP00000009679.5, ENSMUST00000009679.11
      Conserved Domains (1) summary
      pfam03291
      Location:125464
      Pox_MCEL; mRNA capping enzyme

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      68433406..68457923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246991.4XP_011245293.1  mRNA cap guanine-N7 methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_011245293.1

      UniProtKB/Swiss-Prot
      Q9D0L8
      Conserved Domains (1) summary
      pfam03291
      Location:125464
      Pox_MCEL; mRNA capping enzyme
    2. XM_006526193.5XP_006526256.1  mRNA cap guanine-N7 methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006526256.1

      UniProtKB/Swiss-Prot
      Q9D0L8
      Conserved Domains (1) summary
      pfam03291
      Location:125464
      Pox_MCEL; mRNA capping enzyme
    3. XM_006526197.5XP_006526260.1  mRNA cap guanine-N7 methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006526260.1

      UniProtKB/Swiss-Prot
      Q9D0L8
      Conserved Domains (1) summary
      pfam03291
      Location:125464
      Pox_MCEL; mRNA capping enzyme

    RNA

    1. XR_004939884.1 RNA Sequence

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