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    Ppa1 pyrophosphatase (inorganic) 1 [ Mus musculus (house mouse) ]

    Gene ID: 67895, updated on 28-Aug-2018

    Summary

    Official Symbol
    Ppa1provided by MGI
    Official Full Name
    pyrophosphatase (inorganic) 1provided by MGI
    Primary source
    MGI:MGI:97831
    See related
    Ensembl:ENSMUSG00000020089 Vega:OTTMUSG00000035023
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pyp; 2010317E03Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 58.9), CNS E18 (RPKM 48.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ppa1 in Genome Data Viewer
    Location:
    10 B4; 10 32.25 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (61648621..61674165)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (61111369..61136913)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 20 Neighboring gene oligosaccharyltransferase complex subunit pseudogene Neighboring gene neuropeptide FF receptor 1 Neighboring gene RIKEN cDNA 1700022H01 gene Neighboring gene secretion associated Ras related GTPase 1A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    inorganic diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inorganic diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    pyrophosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    phosphate-containing compound metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphate-containing compound metabolic process IC
    Inferred by Curator
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    inorganic pyrophosphatase
    Names
    PPase
    pyrophosphate phospho-hydrolase
    NP_080714.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026438.4NP_080714.2  inorganic pyrophosphatase

      See identical proteins and their annotated locations for NP_080714.2

      Status: PROVISIONAL

      Source sequence(s)
      AC124421
      Consensus CDS
      CCDS23882.1
      UniProtKB/Swiss-Prot
      Q9D819
      UniProtKB/TrEMBL
      Q4FK49
      Related
      ENSMUSP00000020286.6, OTTMUSP00000048617, ENSMUST00000020286.6, OTTMUST00000089059
      Conserved Domains (1) summary
      cl00217
      Location:4241
      pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      61648621..61674165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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