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    Dennd10 DENN domain containing 10 [ Mus musculus (house mouse) ]

    Gene ID: 67894, updated on 23-Jun-2021

    Summary

    Official Symbol
    Dennd10provided by MGI
    Official Full Name
    DENN domain containing 10provided by MGI
    Primary source
    MGI:MGI:1915144
    See related
    Ensembl:ENSMUSG00000024993
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam4; Fam45a; 1810055E12Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 13.5), placenta adult (RPKM 12.7) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Dennd10 in Genome Data Viewer
    Location:
    19; 19 D3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (60799993..60824673)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (60811555..60836235)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (60887473..60912135)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene nanos C2HC-type zinc finger 1 Neighboring gene eukaryotic translation initiation factor 3, subunit A Neighboring gene microRNA 3084-2 Neighboring gene small nucleolar RNA, H/ACA box 19 Neighboring gene 60S ribosomal protein L26-like Neighboring gene sideroflexin 4 Neighboring gene peroxiredoxin 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in endosome transport via multivesicular body sorting pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of early endosome to late endosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DENN domain-containing protein 10
    Names
    family with sequence similarity 45, member A
    protein FAM45A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167829.2NP_001161301.1  DENN domain-containing protein 10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK007867, AK145769, BY122265, BY381661, BY754601
      UniProtKB/Swiss-Prot
      Q9D8N2
      Conserved Domains (1) summary
      pfam09794
      Location:139241
      Avl9; Transport protein Avl9
    2. NM_001347464.1NP_001334393.1  DENN domain-containing protein 10 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC163019, BY381661
      Consensus CDS
      CCDS84460.1
      UniProtKB/TrEMBL
      Q3TH34
      Conserved Domains (1) summary
      pfam08616
      Location:37143
      SPA; Stabilization of polarity axis
    3. NM_001360619.1NP_001347548.1  DENN domain-containing protein 10 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC163019, AK168474, BY381661
      Consensus CDS
      CCDS84460.1
      Related
      ENSMUSP00000112839.2, ENSMUST00000119633.8
      Conserved Domains (1) summary
      pfam08616
      Location:37143
      SPA; Stabilization of polarity axis
    4. NM_001360620.1NP_001347549.1  DENN domain-containing protein 10 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC163019, BY381661
      Conserved Domains (1) summary
      pfam08616
      Location:185291
      SPA; Stabilization of polarity axis
    5. NM_026437.4NP_080713.2  DENN domain-containing protein 10 isoform 1

      See identical proteins and their annotated locations for NP_080713.2

      Status: VALIDATED

      Source sequence(s)
      AK007867, AK145769, BY122265, BY381661, BY754601
      Consensus CDS
      CCDS29942.1
      UniProtKB/Swiss-Prot
      Q9D8N2
      Related
      ENSMUSP00000025957.9, ENSMUST00000025957.9
      Conserved Domains (1) summary
      pfam08616
      Location:158264
      SPA; Stabilization of polarity axis

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      60799993..60824673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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